Solvent/ligand-controlled switchable C3 or C7 C–H arylations of 1-methyl-4-nitro-1H-indazole
Résumé
A new solvent/ligand-controlled switchable C–H arylation of 1-methyl-4-nitro-1H-indazole catalyzed by Pd(OAc)2 was achieved. A bidentate ligand in DMA promoted the activation at C7 position, while a phosphine ligand in H2O oriented the arylation at C3 position. The C3 and C7 arylation products were obtained in moderate to good yields and with high regioselectivity.
Domaines
Chimie| Origine | Fichiers produits par l'(les) auteur(s) |
|---|