Solvent/ligand-controlled switchable C3 or C7 C–H arylations of 1-methyl-4-nitro-1H-indazole - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2022

Solvent/ligand-controlled switchable C3 or C7 C–H arylations of 1-methyl-4-nitro-1H-indazole

Résumé

A new solvent/ligand-controlled switchable C–H arylation of 1-methyl-4-nitro-1H-indazole catalyzed by Pd(OAc)2 was achieved. A bidentate ligand in DMA promoted the activation at C7 position, while a phosphine ligand in H2O oriented the arylation at C3 position. The C3 and C7 arylation products were obtained in moderate to good yields and with high regioselectivity.

Domaines

Chimie
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Dates et versions

hal-03811785 , version 1 (12-10-2022)

Identifiants

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Khalid Boujdi, Nabil El Brahmi, Sylvain Collet, Didier Dubreuil, Monique Mathé-Allainmat, et al.. Solvent/ligand-controlled switchable C3 or C7 C–H arylations of 1-methyl-4-nitro-1H-indazole. Synthesis: Journal of Synthetic Organic Chemistry, 2022, ⟨10.1055/a-1891-0797⟩. ⟨hal-03811785⟩
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