CENP-A, a histone H3 variant with key roles in centromere architecture in healthy and diseased states
Résumé
Centromeres are key architectural components of chromosomes. Here, we examine their construction, maintenance, and functionality. Focusing on the mammalian centromerespecific histone H3 variant, CENP-A, we highlight its co-evolution with both centromeric DNA and its chaperone, HJURP. We then consider CENP-A de novo deposition and the importance of centromeric DNA recently uncovered with the added value from new ultra-long-read sequencing. We next review how to ensure the maintenance of CENP-A at the centromere throughout the cell cycle. Finally, we discuss the impact of disrupting CENP-A regulation on cancer and cell fate.
Mots clés
Centromere
CENP-A
alpha-satellite
HJURP
histone variant
genome architecture
cell cycle
cancer CCAN: Constitutive Centromere Associated Network CDE: Cell cycle-Dependent Element CDK: Cyclin Dependent Kinase CENP-A: Centromere Protein A CHR: Cell cycle genes Homology Region CIN: Chromosomal Instability DREAM: Dimerization partner
Rb-like
E2F
And MuvB EMT: Epithelial-to-Mesenchymal Transition
Domaines
Sciences du Vivant [q-bio]
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220202_Jeffery et al_AcceptedManuscript_textFigures[1].pdf (9.26 Mo)
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