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Chapitre D'ouvrage Année : 2022

CENP-A, a histone H3 variant with key roles in centromere architecture in healthy and diseased states

Résumé

Centromeres are key architectural components of chromosomes. Here, we examine their construction, maintenance, and functionality. Focusing on the mammalian centromerespecific histone H3 variant, CENP-A, we highlight its co-evolution with both centromeric DNA and its chaperone, HJURP. We then consider CENP-A de novo deposition and the importance of centromeric DNA recently uncovered with the added value from new ultra-long-read sequencing. We next review how to ensure the maintenance of CENP-A at the centromere throughout the cell cycle. Finally, we discuss the impact of disrupting CENP-A regulation on cancer and cell fate.
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Dates et versions

hal-03810681 , version 1 (11-10-2022)

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  • HAL Id : hal-03810681 , version 1

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Daniel Jeffery, Marina Lochhead, Geneviève Almouzni. CENP-A, a histone H3 variant with key roles in centromere architecture in healthy and diseased states. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine, In press. ⟨hal-03810681⟩
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