Review of industry reports on EU priority tobacco additives part A: Main outcomes and conclusions
Anne Havermans
(1)
,
Nadja Mallock
(2)
,
Efthimios Zervas
(3, 4)
,
Stéphanie Caillé-Garnier
(5)
,
Thibault Mansuy
(6)
,
Cécile Michel
(6)
,
Jeroen L A Pennings
(1)
,
Thomas Schulz
(2)
,
Per E Schwarze
(7, 8)
,
Renata Solimini
(8)
,
Jean-Pol Tassin
(9, 10)
,
Constantine I Vardavas
(11)
,
Miguel Merino
(12)
,
Charlotte G G M Pauwels
(1)
,
Lotte E van Nierop
(1)
,
Claude Lambré
(13)
,
Anette K Bolling
(7, 8)
1
RIVM -
National Institute for Public Health and the Environment [Bilthoven]
2 BfR - German Federal Institute for Risk Assessment [Berlin]
3 Hellenic Open University [Patras]
4 Hellenic Thoracic Society
5 UB - Université de Bordeaux
6 DER - Direction de l'Evaluation des Risques
7 NIPH - Norwegian Institute of Public Health [Oslo]
8 ISS - Istituto Superiore di Sanità = National Institute of Health
9 UP1 - Université Paris 1 Panthéon-Sorbonne
10 NPS - Neuroscience Paris Seine
11 Hellenic Cancer Society
12 AGAPA - Andalusia Agency For Agriculture and Fisheries Development
13 INRS (Paris) - Institut national de recherche et de sécurité (Paris)
2 BfR - German Federal Institute for Risk Assessment [Berlin]
3 Hellenic Open University [Patras]
4 Hellenic Thoracic Society
5 UB - Université de Bordeaux
6 DER - Direction de l'Evaluation des Risques
7 NIPH - Norwegian Institute of Public Health [Oslo]
8 ISS - Istituto Superiore di Sanità = National Institute of Health
9 UP1 - Université Paris 1 Panthéon-Sorbonne
10 NPS - Neuroscience Paris Seine
11 Hellenic Cancer Society
12 AGAPA - Andalusia Agency For Agriculture and Fisheries Development
13 INRS (Paris) - Institut national de recherche et de sécurité (Paris)
Anne Havermans
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1160818
- ORCID : 0000-0003-2874-6560
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Nadja Mallock
- Fonction : Auteur
- PersonId : 1160829
- ORCID : 0000-0002-7109-0766
Efthimios Zervas
- Fonction : Auteur
- PersonId : 1160830
- ORCID : 0000-0001-7355-2285
- IdRef : 195520386
Stéphanie Caillé-Garnier
- Fonction : Auteur
- PersonId : 742507
- IdHAL : stephanie-caille
- ORCID : 0000-0002-4906-3091
- IdRef : 159732069
Thibault Mansuy
- Fonction : Auteur
- PersonId : 1160831
- ORCID : 0000-0002-0638-3060
Cécile Michel
- Fonction : Auteur
- PersonId : 1366371
- ORCID : 0000-0002-1859-8480
- IdRef : 086999788
Jeroen L A Pennings
- Fonction : Auteur
- PersonId : 1160833
- ORCID : 0000-0002-9188-6358
Per E Schwarze
- Fonction : Auteur
- PersonId : 1160834
- ORCID : 0000-0002-6814-0910
Renata Solimini
- Fonction : Auteur
- PersonId : 1160815
- ORCID : 0000-0001-8737-4504
Jean-Pol Tassin
- Fonction : Auteur
- PersonId : 1160835
- ORCID : 0000-0001-6658-9581
Constantine I Vardavas
- Fonction : Auteur
- PersonId : 1160836
- ORCID : 0000-0003-0171-9570
Charlotte G G M Pauwels
- Fonction : Auteur
- PersonId : 1160837
- ORCID : 0000-0001-6727-0804
Anette K Bolling
- Fonction : Auteur
- PersonId : 1160838
- ORCID : 0000-0003-4209-7448
Résumé
The European Union Tobacco Products Directive (EU TPD) mandates enhanced reporting obligations for tobacco manufacturers regarding 15 priority additives. Within the Joint Action on Tobacco Control (JATC), a review panel of independent experts was appointed for the scientific evaluation of the additive reports submitted by a consortium of 12 tobacco manufacturers. As required by the TPD, the reports were evaluated based on their comprehensiveness, methodology and conclusions. In addition, we evaluated the chemical, toxicological, addictive, inhalation facilitating and flavoring properties of the priority additives based on the submitted reports, supplemented by the panel's expert knowledge and some independent literature. The industry concluded that none of the additives is associated with concern. Due to significant methodological limitations, we question the scientific validity of these conclusions and conclude that they are not warranted. Our review demonstrates that many issues regarding toxicity, addictiveness and attractiveness of the additives have not been sufficiently addressed, and therefore concerns remain. For example, menthol facilitates inhalation by activation of the cooling receptor TRPM8. The addition of sorbitol and guar gum leads to a significant increase of aldehydes that may contribute to toxicity and addictiveness. Titanium dioxide particles (aerodynamic diameter <10 µm) are legally classified as carcinogenic when inhaled. For diacetyl no report was provided. Overall, the industry reports were not comprehensive, and the information presented provides an insufficient basis for the regulation of most additives. We, therefore, advise MS to consider alternative approaches such as the precautionary principle.
Domaines
Sciences cognitives Sciences cognitives Sciences du Vivant [q-bio] Sciences du Vivant [q-bio]Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Review of industry reports on EU priority tobacco additives part A: Main outcomes and conclusions
|
Résumé |
en
The European Union Tobacco Products Directive (EU TPD) mandates enhanced reporting obligations for tobacco manufacturers regarding 15 priority additives. Within the Joint Action on Tobacco Control (JATC), a review panel of independent experts was appointed for the scientific evaluation of the additive reports submitted by a consortium of 12 tobacco manufacturers. As required by the TPD, the reports were evaluated based on their comprehensiveness, methodology and conclusions. In addition, we evaluated the chemical, toxicological, addictive, inhalation facilitating and flavoring properties of the priority additives based on the submitted reports, supplemented by the panel's expert knowledge and some independent literature. The industry concluded that none of the additives is associated with concern. Due to significant methodological limitations, we question the scientific validity of these conclusions and conclude that they are not warranted. Our review demonstrates that many issues regarding toxicity, addictiveness and attractiveness of the additives have not been sufficiently addressed, and therefore concerns remain. For example, menthol facilitates inhalation by activation of the cooling receptor TRPM8. The addition of sorbitol and guar gum leads to a significant increase of aldehydes that may contribute to toxicity and addictiveness. Titanium dioxide particles (aerodynamic diameter <10 µm) are legally classified as carcinogenic when inhaled. For diacetyl no report was provided. Overall, the industry reports were not comprehensive, and the information presented provides an insufficient basis for the regulation of most additives. We, therefore, advise MS to consider alternative approaches such as the precautionary principle.
|
Auteur(s) |
Anne Havermans
1
, Nadja Mallock
2
, Efthimios Zervas
3, 4
, Stéphanie Caillé-Garnier
5
, Thibault Mansuy
6
, Cécile Michel
6
, Jeroen L A Pennings
1
, Thomas Schulz
2
, Per E Schwarze
7, 8
, Renata Solimini
8
, Jean-Pol Tassin
9, 10
, Constantine I Vardavas
11
, Miguel Merino
12
, Charlotte G G M Pauwels
1
, Lotte E van Nierop
1
, Claude Lambré
13
, Anette K Bolling
7, 8
1
RIVM -
National Institute for Public Health and the Environment [Bilthoven]
( 453112 )
- Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven / PO Box 1, 3720 BA Bilthoven
- Pays-Bas
2
BfR -
German Federal Institute for Risk Assessment [Berlin]
( 555964 )
- Allemagne
3
Hellenic Open University [Patras]
( 470701 )
- Grèce
4
Hellenic Thoracic Society
( 1124348 )
- Grèce
5
UB -
Université de Bordeaux
( 259761 )
- 35, place Pey Berland - 33076 Bordeaux
- France
6
DER -
Direction de l'Evaluation des Risques
( 529263 )
- 14 rue Pierre et Marie Curie
94701 Maisons-Alfort
- France
7
NIPH -
Norwegian Institute of Public Health [Oslo]
( 92344 )
- PO Box 222 Skøyen
N-0213 Oslo
- Norvège
8
ISS -
Istituto Superiore di Sanità = National Institute of Health
( 359183 )
- 299, Viale Regina Elena, 00161 – Roma
- Italie
9
UP1 -
Université Paris 1 Panthéon-Sorbonne
( 7550 )
- 12 place du Panthéon, 75231 Paris Cedex 05
- France
10
NPS -
Neuroscience Paris Seine
( 542136 )
- Campus Jussieu - 9 quai Saint-Bernard - Bâtiment B/4ème étage - 75252 Paris cedex 05
- France
11
Hellenic Cancer Society
( 1124349 )
- 18-20, A. Tsoha Street
GR-11521 Athens
- Grèce
12
AGAPA -
Andalusia Agency For Agriculture and Fisheries Development
( 1124350 )
- Agencia de Gestión Agraria y Pesquera
C. Bergantín, 39, 41012 Sevilla
- Espagne
13
INRS (Paris) -
Institut national de recherche et de sécurité (Paris)
( 470398 )
- 65, boulevard Richard- Lenoir 75011 Paris
- France
|
Licence |
Paternité
|
Date de publication électronique |
2022-06-24
|
URL éditeur |
http://www.tobaccopreventioncessation.com/Review-of-industry-reports-on-EU-priority-tobacco-additives-part-A-Main-outcomes,151529,0,2.html
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2022-07-05
|
Volume |
8
|
Page/Identifiant |
1 - 18
|
Mots-clés (Mesh) |
|
Projet(s) Européen(s) |
|
Domaine(s) |
|
Mots-clés |
en
Tobacco additives, Toxicity, Addictiveness, Inhalation facilitation, Attractiveness, Tobacco regulation, Public Policy
|
DOI | 10.18332/tpc/151529 |
Pubmed Id | 35860504 |
PubMed Central | PMC9255285 |
Fichier principal
2022-JATC Havermans et al Part A Tobacco Prevention & Cessation.pdf ( 189.57 Ko
)
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