Article Dans Une Revue ChemPhysChem Année : 2022

Anisotropic 1H STD‐NMR Spectroscopy: Exploration of Enantiomer‐Polypeptide Interactions in Chiral Oriented Environments

Résumé

We explore and report for the first time the use of 1H saturation transfer difference NMR experiments (STD-NMR) in weakly-aligning chiral anisotropic media to identify the hydrogen sites of enantiomers of small chiral molecules interacting with the side-chain of poly-γ-benzyl-L-glutamate (PBLG), a helically chiral polypeptide polymer. The first experimental results obtained on three model mono-stereogenic compounds outcomes are highly promising and demonstrate the possibility to track down possible differences of spatial position of enantiomers at the vicinity of the polymer side-chain. Anisotropic STD experiments appear to be well suited for rapid screening of chiral analytes that bind favorably to orienting polymeric systems, while providing new insights into the mechanism of enantio-discrimination without resorting to the time-consuming determination of molecular order parameters.

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hal-03800520 , version 1 (11-03-2023)

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Boris Gouilleux, Francois-Marie Moussallieh, Philippe Lesot. Anisotropic 1H STD‐NMR Spectroscopy: Exploration of Enantiomer‐Polypeptide Interactions in Chiral Oriented Environments. ChemPhysChem, 2022, 24 (4), pp.e202200508. ⟨10.1002/cphc.202200508⟩. ⟨hal-03800520⟩
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