Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Pineal Research Année : 2022

Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2

Erika Cecon
Sophie Le Poder
Fernando Real
Aiwei Zhu
  • Fonction : Auteur
Bernard Klonjkowski
Ralf Jockers
Julie Dam

Résumé

As the COVID-19 pandemic grows, several therapeutic candidates are being tested or undergoing clinical trials. Although prophylactic vaccination against SARS-CoV-2 infection has been shown to be effective, no definitive treatment exists to date in the event of infection. The rapid spread of infection by SARS-CoV-2 and its variants fully warrants the continued evaluation of drug treatments for COVID-19, especially in the context of repurposing of already available and safe drugs. Here, we explored the therapeutic potential of melatonin and melatonergic compounds in attenuating COVID-19 pathogenesis in mice expressing human ACE2 receptor (K18-hACE2), strongly susceptible to SARS-CoV-2 infection. Daily administration of melatonin, agomelatine, or ramelteon delays the occurrence of severe clinical outcome with improvement of survival, especially with high melatonin dose. Although no changes in most lung inflammatory cytokines are observed, treatment with melatonergic compounds limits the exacerbated local lung production of type I and type III interferons, which is likely associated with the observed improved symptoms in treated mice. The promising results from this preclinical study should encourage studies examining the benefits of repurposing melatonergic drugs to treat COVID-19 and related diseases in humans.
Fichier principal
Vignette du fichier
Cecon et al Manuscript-revised-NO tracked changes.pdf (375.05 Ko) Télécharger le fichier
Cecon et al Figures.pdf (4.96 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03800421 , version 1 (07-10-2022)

Identifiants

Citer

Erika Cecon, Charlotte Izabelle, Sophie Le Poder, Fernando Real, Aiwei Zhu, et al.. Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2. Journal of Pineal Research, 2022, 72 (1), pp.e12772. ⟨10.1111/jpi.12772⟩. ⟨hal-03800421⟩
94 Consultations
137 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More