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Article Dans Une Revue Organic Process Research and Development Année : 2022

Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?

Résumé

The concept and practices of chemical synthesis are being profoundly transformed toward the development of fully autonomous continuous processes. Critical to the development of autonomous continuous processes is the efficient monitoring of the reaction composition and product quality by in-line and online analyses. The in-line/online acquisition of analytical data allows to monitor at regular interval the reaction composition including hazardous or air sensitive intermediates with the possibility of adapting reaction parameters or interrupt the flow process when a chemical or technical failure is detected. This review presents the main in-line/online analytical tools which can be integrated into flow reactors for the monitoring of chemical reactions. This contribution is more a guide at the service of synthetic chemists illustrated by selected published examples from leading research laboratories than an exhaustive list of published articles. Ultimately, we would like this review to be an answer to the following recurrent, yet complex, question: “Which is/are the most suitable analytical solution(s) to monitor my chemical reaction?”.

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Chimie
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Dates et versions

hal-03800179 , version 1 (06-10-2022)

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Mireia Rodriguez-Zubiri, François-Xavier Felpin. Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?. Organic Process Research and Development, 2022, 26 (6), pp.1766-1793. ⟨10.1021/acs.oprd.2c00102⟩. ⟨hal-03800179⟩
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