Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2aminothiophene have recently focused interest because 2-aminothiophene is a unique 5membered S-heterocycle and a pharmacophore providing antiprotozoal, antiproliferative, antiviral, antibacterial or antifungal properties. Here, we review new synthetic routes to 2aminothiophenes, including multicomponent reactions, homogeneously-or heterogeneouslycatalyzed reactions, with focus on green pathways.