Transcriptional Regulation of Mononuclear Phagocyte Development - Archive ouverte HAL
Article Dans Une Revue Frontiers in Immunology Année : 2015

Transcriptional Regulation of Mononuclear Phagocyte Development

Transcriptional Regulation of Mononuclear Phagocyte Development.

Résumé

Mononuclear phagocytes (MP) are a quite unique subset of hematopoietic cells, which comprise dendritic cells (DC), monocytes as well as monocyte-derived and tissue-resident macrophages. These cells are extremely diverse with regard to their origin, their phenotype as well as their function. Developmentally, DC and monocytes are constantly replenished from a bone marrow hematopoietic progenitor. The ontogeny of macrophages is more complex and is temporally linked and specified by the organ where they reside, occurring early during embryonic or perinatal life. The functional heterogeneity of MPs is certainly a consequence of the tissue of residence and also reflects the diverse ontogeny of the subsets. In this review, we will highlight the developmental pathways of murine MP, with a particular emphasis on the transcriptional factors that regulate their development and function. Finally, we will discuss and point out open questions in the field.

Dates et versions

hal-03798238 , version 1 (05-10-2022)

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Citer

Roxane Tussiwand, Emmanuel Gautier. Transcriptional Regulation of Mononuclear Phagocyte Development. Frontiers in Immunology, 2015, 6, pp.533. ⟨10.3389/fimmu.2015.00533⟩. ⟨hal-03798238⟩
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