The urban ecosystem is a very challenging environment that faces many problems such as various pollutions, higher temperatures than its surroundings or flooding risks due to soil sealing. Nature-based solutions (NBS) seem to be good option to address these problems, while simultaneously offering benefits for facing climate change and the biodiversity crisis. Despite their potential, NBS can be threatened by various urban disturbance, namely: land use change, pollution, or invasive species. These disturbances can have multiple consequences on urban NBS, such as causing changes in plant characteristics/traits, altering the services they provide, and even make certain plant populations disappear, etc. In turn, these consequences may even jeopardize the solutions themselves, which then may no longer solve the problems they originally targeted. To avoid this, NBS should be eco-designed, i.e. designed in function of their environment. Their management should be adaptive and should also take into consideration the evolution of climatic and anthropogenic factors. The choice of species should not be left to chance or random: In this sense, is it better to plant native species for biodiversity conservation or exotic species that are more likely to resist global changes? Is it better to find resistant or ruderal species that have proven themselves in the face of certain disturbances? In any case, it would be good to diversify any NBS to have a better chance of survival in the face of global changes.