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Journal Articles Science Year : 2022

Codiversification of gut microbiota with humans

Taichi Suzuki
J. Liam Fitzstevens
Hagay Enav
Kelsey Huus
Mirabeau Mbong Ngwese
Bayode R. Adegbite
  • Function : Author
Jeannot Zinsou
Meral Esen
Ayola Adegnika
Timothy Spector
Amanda Muehlbauer
Ran Blekhman
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  • PersonId : 1046906
Nicholas Youngblut
Peter Kremsner
Ruth. E Ley

Abstract

The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.
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hal-03796464 , version 1 (04-10-2022)

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Taichi Suzuki, J. Liam Fitzstevens, Victor Schmidt, Hagay Enav, Kelsey Huus, et al.. Codiversification of gut microbiota with humans. Science, 2022, 377 (6612), pp.1328-1332. ⟨10.1126/science.abm7759⟩. ⟨hal-03796464⟩
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