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Article Dans Une Revue IDCases Année : 2022

Concomitant and productive genital infections by HSV-2 and HPV in two young women: A case report

Christelle Graf
  • Fonction : Auteur
Marine Bonneau
  • Fonction : Auteur
Michel Segondy
  • Fonction : Auteur
Nathalie Boulle
  • Fonction : Auteur
Vincent Tribout
  • Fonction : Auteur

Résumé

Human papillomaviruses (HPVs), the most oncogenic virus known to humans, are often associated with Herpes Simplex Virus-2 (HSV-2) infections. The involvement of the latter in cervical cancer is controversial but its longterm infections might modulate the mucosal microenvironment in a way that favors carcinogenesis. We know little about coinfections between HSV-2 and HPVs, and studying the immunological and microbiological dynamics in the early stages of these infections may help identify or rule out potential interactions. We report two cases of concomitant productive, although asymptomatic, HSV-2 and HPV infections in young women (aged 20 and 25). The women were followed up for approximately a year, with clinical visits every two months and weekly self-samples. We performed quantitative analyses of their HSV-2 and HPV viral loads, immunological responses (IgG and IgM antibodies and local cytokines expression profiles), vaginal microbiota composition, as well as demographic and behavior data. We detect interactions between virus loads, immune response, and the vaginal microbiota, which improve our understanding of HSV-2 and HPVs' coinfections and calls for further investigation with larger cohorts.
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Dates et versions

hal-03795483 , version 1 (04-10-2022)

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Ilkay Başak Uysal, Vanina Boué, Carmen Lia Murall, Christelle Graf, Christian Selinger, et al.. Concomitant and productive genital infections by HSV-2 and HPV in two young women: A case report. IDCases, 2022, 30, pp.e01604. ⟨10.1016/j.idcr.2022.e01604⟩. ⟨hal-03795483⟩
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