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            <funder>SL and ARD. were recipients of doctoral fellowships from Normandy Region and The Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation, respectively. This work was supported by INSERM (U1239), Rouen University, Normandy Region and European Union. Europe gets involved in Normandie with European Regional Development Fund (ERDF).</funder>
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            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
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                <term xml:lang="en">Apnea of prematurity</term>
                <term xml:lang="en">Intermittent hypoxia</term>
                <term xml:lang="en">Cerebellum</term>
                <term xml:lang="en">Purkinje cells</term>
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              <p>Background: Apnea of prematurity (AOP) is caused by respiratory control immaturity and affects nearly 50% of premature newborns. This pathology induces perinatal intermittent hypoxia (IH), which leads to neurodevelopmental disorders. The impact on the brain has been well investigated. However, despite its functional importance and immaturity at birth, the involvement of the cerebellum remains poorly understood. Therefore, this study aims to identify the effects of IH on cerebellar development using a mouse model of AOP consisting of repeated 2-min cycles of hypoxia and reoxygenation over 6 h and for 10 days starting on postnatal day 2 (P2).Results At P12, IH-mice cerebella present higher oxidative stress associated with delayed maturation of the cerebellar cortex and decreased dendritic arborization of Purkinje cells. Moreover, mice present with growth retardation and motor disorders. In response to hypoxia, the developing cerebellum triggers compensatory mechanisms resulting in the unaltered organization of the cortical layers from P21 onwards. Nevertheless, some abnormalities remain in adult Purkinje cells, such as the dendritic densification, the increase in afferent innervation, and axon hypomyelination. Moreover, this compensation seems insufficient to allow locomotor recovery because adult mice still show motor impairment and significant disorders in spatial learning.Conclusions All these findings indicate that the cerebellum is a target of intermittent hypoxia through alterations of developmental mechanisms leading to long-term functional deficits. Thus, the cerebellum could contribute, like others brain structures, to explaining the pathophysiology of AOP.</p>
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