Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case‐control studies ( SYNERGY ) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Cancer Année : 2022

Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case‐control studies ( SYNERGY )

Per Gustavsson
  • Fonction : Auteur
Dario Mirabelli
  • Fonction : Auteur
Dario Consonni
  • Fonction : Auteur
Neil Caporaso
  • Fonction : Auteur
Maria Teresa Landi
  • Fonction : Auteur
John Field
  • Fonction : Auteur
Stefan Karrasch
  • Fonction : Auteur
Heinz-Erich Wichmann
  • Fonction : Auteur
Jack Siemiatycki
  • Fonction : Auteur
Marie-Elise Parent
  • Fonction : Auteur
Lorenzo Richiardi
  • Fonction : Auteur
Lorenzo Simonato
  • Fonction : Auteur
Wolfgang Ahrens
  • Fonction : Auteur
Hermann Pohlabeln
  • Fonction : Auteur
Guillermo Fernández-Tardón
  • Fonction : Auteur
David Zaridze
  • Fonction : Auteur
John Mclaughlin
  • Fonction : Auteur
Paul Demers
  • Fonction : Auteur
Beata Świątkowska
  • Fonction : Auteur
Jolanta Lissowska
  • Fonction : Auteur
Tamás Pándics
  • Fonction : Auteur
Eleonora Fabianova
  • Fonction : Auteur
Dana Mates
  • Fonction : Auteur
Vladimir Bencko
  • Fonction : Auteur
Lenka Foretova
  • Fonction : Auteur
Vladimír Janout
  • Fonction : Auteur
Paolo Boffetta
  • Fonction : Auteur
Bas Bueno-De-Mesquita
  • Fonction : Auteur
Francesco Forastiere
  • Fonction : Auteur
Kurt Straif
  • Fonction : Auteur

Résumé

There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure levels to Cr(VI) and nickel, which were linked to the subjects' occupational histories. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated by unconditional logistic regression, adjusting for study, age group, smoking habits and exposure to other occupational lung carcinogens. Due to their high correlation, we refrained from mutually adjusting for Cr(VI) and nickel independently. In men, ORs for the highest quartile of cumulative exposure to CR(VI) were 1.32 (95% CI 1.19-1.47) and 1.29 (95% CI 1.15-1.45) in relation to nickel. Analogous results among women were: 1.04 (95% CI 0.48-2.24) and 1.29 (95% CI 0.60-2.86), respectively. In men, excess lung-cancer risks due to occupational Cr(VI) and nickel exposure were also observed in each stratum of never, former and current smokers. Joint effects of Cr(VI) and nickel with smoking were in general greater than additive, but not different from multiplicative. In summary, relatively low cumulative levels of occupational exposure to Cr(VI) and nickel were associated with increased ORs for lung cancer, particularly in men. However, we cannot rule out a combined classical measurement and Berkson-type of error structure, which may cause differential bias of risk estimates.
Fichier principal
Vignette du fichier
Behrens et al. - 2022 - Occupational exposure to nickel and hexavalent chr (1).pdf (2.41 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03789594 , version 1 (20-12-2022)

Identifiants

Citer

Thomas Behrens, Calvin Ge, Roel Vermeulen, Benjamin Kendzia, Ann Olsson, et al.. Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case‐control studies ( SYNERGY ). International Journal of Cancer, 2022, ⟨10.1002/ijc.34272⟩. ⟨hal-03789594⟩
93 Consultations
85 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More