Prevalence of psychoactive drug use in patients hospitalized for acute cardiac events: Rationale and design of the ADDICT-ICCU trial, from the Emergency and Acute Cardiovascular Care Working Group and the National College of Cardiologists in Training of the French Society of Cardiology - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Archives of cardiovascular diseases Année : 2022

Prevalence of psychoactive drug use in patients hospitalized for acute cardiac events: Rationale and design of the ADDICT-ICCU trial, from the Emergency and Acute Cardiovascular Care Working Group and the National College of Cardiologists in Training of the French Society of Cardiology

1 Hôpital Lariboisière-Fernand-Widal [APHP]
2 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
3 CHU Rouen
4 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
5 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
6 Nouvel Hôpital Civil de Strasbourg
7 Hôpital Haut-Lévêque [CHU Bordeaux]
8 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
9 CHU Caen
10 Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Pré, Pierre Cherest, Hartmann]
11 CHI André Gregoire - Centre Hospitalier Intercommunal André Grégoire [Montreuil]
12 Groupe Hospitalier Intercommunal Le Raincy-Montfermeil
13 Hôpitaux de Chartres [Chartres]
14 CHU de la Martinique [Fort de France]
15 CHI Fréjus - St Raphaël - Centre Hospitalier Intercommunal Fréjus - St Raphaël
16 Hôpital Avicenne [AP-HP]
17 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
18 UPCité - Université Paris Cité
19 Hôpital Cochin [AP-HP]
20 Hôpital d'instruction des Armées Percy
21 Hôpital Ambroise Paré [AP-HP]
22 CHV - Centre Hospitalier de Versailles André Mignot
23 CTSGA - Nouvelle Clinique de Tours Saint Gatien-Alliance [Tours]
24 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
25 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
26 UM - Université de Montpellier
27 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
28 Hôpital Dupuytren [CHU Limoges]
29 NET - Neuroépidémiologie Tropicale
30 HEGP - Hôpital Européen Georges Pompidou [APHP]
31 CHU Saint-Antoine [AP-HP]
Charles Fauvel
  • Fonction : Auteur
Vincent Roule
  • Fonction : Auteur
Alain Grentzinger
  • Fonction : Auteur
Eric Vicaut

Résumé

Background: Psychoactive drugs, including illicit drugs, are associated with an increased rate of cardiovascular events. The prevalence and outcome of patients using these drugs at the time of admission to an intensive cardiac care unit is unknown. Aim: To assess the prevalence of psychoactive drugs detected in consecutive patients hospitalized in an intensive cardiac care unit for an acute cardiovascular event. Methods: This is a nationwide prospective multicentre study, involving 39 centres throughout France, including all consecutive patients hospitalized in an intensive cardiac care unit within 2weeks. Psychoactive drug use will be assessed systematically by urine drug assay within 2hours of intensive cardiac care unit admission, to detect illicit (cannabinoids, cocaine, amphetamines, ecstasy, heroin and other opioids) and non-illicit (barbiturates, benzodiazepines, tricyclic antidepressants, methadone and buprenorphine) psychoactive drugs. Smoking will be investigated systematically by exhaled carbon monoxide measurement, and alcohol consumption using a standardized questionnaire. In-hospital major adverse events, including death, resuscitated cardiac arrest and cardiogenic shock, will be recorded. After discharge, all-cause death and major adverse cardiovascular events will be recorded systematically and adjudicated at 12months of follow-up. Results: The primary outcome will be the prevalence of psychoactive drugs detected by systematic screening among all patients hospitalized in an intensive cardiac care unit. The in-hospital major adverse events will be analysed according to the presence or absence of detected psychoactive drugs. Subgroup analysis stratified by initial clinical presentation and type of psychoactive drug will be performed. Conclusions: This is the first prospective multicentre study to assess the prevalence of psychoactive drugs detected by systematic screening in consecutive patients hospitalized for acute cardiovascular events.
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Dates et versions

hal-03789560 , version 1 (04-11-2022)

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Jean-Guillaume Dillinger, Théo Pezel, Charles Fauvel, Clément Delmas, Guillaume Schurtz, et al.. Prevalence of psychoactive drug use in patients hospitalized for acute cardiac events: Rationale and design of the ADDICT-ICCU trial, from the Emergency and Acute Cardiovascular Care Working Group and the National College of Cardiologists in Training of the French Society of Cardiology. Archives of cardiovascular diseases, 2022, ⟨10.1016/j.acvd.2022.05.012⟩. ⟨hal-03789560⟩
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