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                <title level="j">Transfusion Medicine</title>
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                <term xml:lang="en">transfusion practice</term>
                <term xml:lang="en">randomised clinical trial</term>
                <term xml:lang="en">platelets transfusion</term>
                <term xml:lang="en">pathogen reduction</term>
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              <p>ObjectiveTo evaluate the impact of pathogen-reduced (PR) platelet transfusions on blood products requirement for clinical practice.BackgroundPR platelets are increasing in use as standard blood products. However, few randomised trials have evaluated their impact on bleeding control or prevention. Furthermore, PR platelets recirculate less than untreated platelets.MethodsA subgroup study of the randomised clinical trial EFFIPAP compared three arms of platelet preparations (PR: P-PRP/PAS, additive solution: P-PAS and plasma P-P arms respectively). The subgroup of acute leukaemia patients, in their chemotherapy induction phase, included 392 patients (133 P-PRP/PAS arm, 132 P-PAS arm and 130 P-P arm). Blood requirements were analysed across over periods of 7 days.ResultsThe number of platelet transfusions per week was significantly higher in the P-PRP/PAS group 2.3 [1.6–3.3] compared to the control groups 1.9 [1.3–2.8] and 2.0 [1.3–3.0] for P-P and P-PAS groups respectively (p &lt; 0.0001). However, the total number of platelets transfused per week was not different. The number of red blood cell concentrates (RBC) transfusion per week did not differ either.ConclusionIn a homogeneous group of patients, platelet pathogen reduction resulted in an increased number of platelet units transfused per week while having no impact on the total number of platelets transfused or the number of RBC transfusion; resulting to an average requirement of 2 RBC and 2–3 platelets transfusions per week of marrow aplasia.</p>
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            <ref type="url">http://www.ubfc.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>