Gold(I)-Catalyzed Domino Reaction : An Access to furooxepines - Archive ouverte HAL
Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2022

Gold(I)-Catalyzed Domino Reaction : An Access to furooxepines

Résumé

We report herein the synthesis of [7,5]-fused bicyclic acetals, also named furooxepines derivatives through a gold(I)-catalyzed domino reaction. During this transformation, two molecules of homopropargyl alcohol react together, in a sequence including an intramolecular hydroalkoxylation, condensation, a 1,6-enyne cycloisomerization, acetalization and an isomerization. This gold(I)-catalyzed domino reaction allow the formation of three bonds, two heterocycles and a tetrasubstituted carbon stereocenters in a one-step operation with 100% atom economy. Post-functionalizations allow the formation of tetrahydrofurans.
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Dates et versions

hal-03778216 , version 1 (15-09-2022)

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Roméric Galéa, Gaëlle Blond. Gold(I)-Catalyzed Domino Reaction : An Access to furooxepines. Advanced Synthesis and Catalysis, 2022, 364 (9), pp.1532-1536. ⟨10.1002/adsc.202200019⟩. ⟨hal-03778216⟩
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