Pickering emulsions stabilized by biodegradable dextran-based nanoparticles featuring enzyme responsiveness and coencapsulation of actives - Archive ouverte HAL Access content directly
Journal Articles Carbohydrate Polymers Year : 2022

Pickering emulsions stabilized by biodegradable dextran-based nanoparticles featuring enzyme responsiveness and coencapsulation of actives

Abstract

In this study, Pickering emulsions of dodecane and medium chain triglyceride (MCT) oils were stabilized by simply alkylated-dextran nanoparticles. Our findings show that very little of these bio-friendly nanoparticles is necessary to stabilize Pickering emulsions while providing a high time stability (more than a year at 37°C). As dextran is known to be cleavable by dextranase enzyme, hydrolysis of the nanoparticles in the presence of dextranase could be achieved. This allowed performing on-demand destabilization of Pickering emulsions. Furthermore, two different fluorescent probes were loaded into the stabilizing particles and the oil droplets respectively, providing a proof of concept for co-encapsulation of actives in advanced delivery applications. Additionally, to a conventional fluorescence probe, quinine, an antimalarial drug was also encapsulated into the nanoparticles.
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Dates and versions

hal-03778180 , version 1 (15-09-2022)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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Valentin Maingret, Coraline Chartier, J.L. Six, Véronique Schmitt, Valérie Héroguez. Pickering emulsions stabilized by biodegradable dextran-based nanoparticles featuring enzyme responsiveness and coencapsulation of actives. Carbohydrate Polymers, 2022, pp.119146. ⟨10.1016/j.carbpol.2022.119146⟩. ⟨hal-03778180⟩
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