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Article Dans Une Revue Microorganisms Année : 2022

Effect of Phthalates and Their Substitutes on the Physiology of Pseudomonas aeruginosa

Julien Verdon
Sophie Rodrigues
Maëliss Manac’h
  • Fonction : Auteur
Baptiste Luton
  • Fonction : Auteur
Marie Le Calvé
  • Fonction : Auteur
Alexis Bazire
Emilie Portier
  • Fonction : Auteur
Laure Taupin
  • Fonction : Auteur
Thomas Clamens
  • Fonction : Auteur
Pierre Cornelis
  • Fonction : Auteur
Jocelyne Caillon
  • Fonction : Auteur
Alain Dufour

Résumé

Phthalates are used in a variety of applications—for example, as plasticizers in polyvinylchloride products to improve their flexibility—and can be easily released into the environment. In addition to being major persistent organic environmental pollutants, some phthalates are responsible for the carcinogenicity, teratogenicity, and endocrine disruption that are notably affecting steroidogenesis in mammals. Numerous studies have thus focused on deciphering their effects on mammals and eukaryotic cells. While multicellular organisms such as humans are known to display various microbiota, including all of the microorganisms that may be commensal, symbiotic, or pathogenic, few studies have aimed at investigating the relationships between phthalates and bacteria, notably regarding their effects on opportunistic pathogens and the severity of the associated pathologies. Herein, the effects of phthalates and their substitutes were investigated on the human pathogen, Pseudomonas aeruginosa, in terms of physiology, virulence, susceptibility to antibiotics, and ability to form biofilms. We show in particular that most of these compounds increased biofilm formation, while some of them enhanced the bacterial membrane fluidity and altered the bacterial morphology.

Dates et versions

hal-03777008 , version 1 (14-09-2022)

Identifiants

Citer

Mélissande Louis, Ali Tahrioui, Julien Verdon, Audrey David, Sophie Rodrigues, et al.. Effect of Phthalates and Their Substitutes on the Physiology of Pseudomonas aeruginosa. Microorganisms, 2022, 10 (9), pp.1788. ⟨10.3390/microorganisms10091788⟩. ⟨hal-03777008⟩
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