To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borreliosis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Microbiology and Infection Année : 2018

To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borreliosis

Ram Benny Christian Dessau
  • Fonction : Auteur
Alje van Dam
  • Fonction : Auteur
Volker Gerdes Lars Fingerle
  • Fonction : Auteur
Jeremy S Gray
  • Fonction : Auteur
Joppe W. R. Hovius
  • Fonction : Auteur
Klaus Peter Hunfeld
  • Fonction : Auteur
Olaf Kahl
  • Fonction : Auteur
Wolfgang Kristoferitsch
  • Fonction : Auteur
Per Eric Lindgren
  • Fonction : Auteur
Mateusz Andrzej Markowicz
  • Fonction : Auteur
Sally Mavin
  • Fonction : Auteur
Katharina Ornstein
  • Fonction : Auteur
Tobias A. Rupprecht
  • Fonction : Auteur
Gerold Stanek
  • Fonction : Auteur
Franc Strle
  • Fonction : Auteur

Résumé

BACKGROUND: Lyme borreliosis (LB) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The most frequent clinical manifestations are erythema migrans and Lyme neuroborreliosis. Currently, a large volume of diagnostic testing for LB is reported, whereas the incidence of clinically relevant disease manifestations is low. This indicates overuse of diagnostic testing for LB with implications for patient care and cost-effective health management. AIM: The recommendations provided in this review are intended to support both the clinical diagnosis and initiatives for a more rational use of laboratory testing in patients with clinically suspected LB. SOURCES: This is a narrative review combining various aspects of the clinical and laboratory diagnosis with an educational purpose. The literature search was based on existing systematic reviews, national and international guidelines and supplemented with specific citations. IMPLICATIONS: The main recommendations according to current European case definitions for LB are as follows. Typical erythema migrans should be diagnosed clinically and does not require laboratory testing. The diagnosis of Lyme neuroborreliosis requires laboratory investigation of the spinal fluid including intrathecal antibody production, and the remaining disease manifestations require testing for serum antibodies to B. burgdorferi. Testing individuals with non-specific subjective symptoms is not recommended, because of a low positive predictive value.

Dates et versions

hal-03776636 , version 1 (13-09-2022)

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Citer

Ram Benny Christian Dessau, Alje van Dam, Volker Gerdes Lars Fingerle, Jeremy S Gray, Joppe W. R. Hovius, et al.. To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borreliosis. Clinical Microbiology and Infection, 2018, 24 (2), pp.118-124. ⟨10.1016/j.cmi.2017.08.025⟩. ⟨hal-03776636⟩

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