Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Optics Continuum Année : 2022

Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin

Charly Gourlot
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Alexis Gosset
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Elise Glattard
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Morgane Rabineau
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Tan-Sothea Ouk
Vincent Sol
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Philippe Lavalle
Christophe Gourlaouen
Burkhard Bechinger
Valérie Heitz

Résumé

The increase of antimicrobial resistance to conventional antibiotics is worldwide a major health problem that requires the development of new bactericidal strategies. Antimicrobial photodynamic therapy (a-PDT) that generates reactive oxygen species acting on multiple cellular targets is unlikely to induce bacterial resistance. This localized treatment requires, for safe and efficient treatment of nonsuperficial infections, a targeting photosensitizer excited in the near IR. To this end, a new conjugate consisting of an antimicrobial peptide linked to a π-extended porphyrin photosensitizer was designed for a-PDT. Upon irradiation at 720 nm, the conjugate has shown at micromolar concentration strong bactericidal action on both Gram-positive and Gram-negative bacteria. Moreover, this conjugate allows one to reach a low minimum bactericidal concentration with near IR excitation without inducing toxicity to skin cells. Keywords: antimicrobial peptide; antimicrobial photodynamic therapy; bacteria; keratinocyte; near infrared; porphyrin.
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Dates et versions

hal-03775697 , version 1 (14-10-2022)

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Charly Gourlot, Alexis Gosset, Elise Glattard, Christopher Aisenbrey, Sabarinathan Rangasamy, et al.. Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin. Optics Continuum , 2022, 8 (8), pp.1509-1520. ⟨10.1021/acsinfecdis.2c00131⟩. ⟨hal-03775697⟩
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