Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development - Archive ouverte HAL Access content directly
Journal Articles Biology Open Year : 2017

Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development

Carole Haushalter
  • Function : Author
Brigitte Schuhbaur
  • Function : Author
Pascal Dollé

Abstract

Retinoic acid (RA) is a diffusible molecule involved in early forebrain patterning. Its later production in the meninges by the retinaldehyde dehydrogenase RALDH2 coincides with the time of cortical neuron generation. A function of RA in this process has not been adressed directly as Raldh2−/− mouse mutants are embryonic lethal. Here we used a conditional genetic strategy to inactivate Raldh2 just prior to its onset of expression in the developing meninges. This inactivation does not affect the formation of the cortical progenitor populations, their rate of division, or timing of differentiation. However, migration of late-born cortical neurons is delayed, with neurons stalling in the intermediate zone and exhibiting an abnormal multipolar morphology. This suggests that RA controls the multipolar-to-bipolar transition which occurs in the intermediate zone and allows neurons to start locomotion in the cortical plate. Our work also shows a role for RA in cortical lamination, as deep layers are expanded and a subset of layer IV neurons are not formed in the Raldh2-ablated mutants. These data demonstrate that meninges are a source of extrinsic signals important for cortical development.

Dates and versions

hal-03774280 , version 1 (10-09-2022)

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Carole Haushalter, Brigitte Schuhbaur, Pascal Dollé, Muriel Rhinn. Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development. Biology Open, 2017, ⟨10.1242/bio.021063⟩. ⟨hal-03774280⟩
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