Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Alzheimer's Disease Année : 2018

Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile

Résumé

Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer’s disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.
Fichier principal
Vignette du fichier
MIGLIACCIO_Lara.pdf (552.69 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01928504 , version 1 (20-11-2018)

Identifiants

Citer

Géraldine Bera, Raffaella Migliaccio, Thibaut Michelin, Foudil Lamari, Sophie Ferrieux, et al.. Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile. Journal of Alzheimer's Disease, 2018, 66 (1), pp.271 - 280. ⟨10.3233/JAD-180087⟩. ⟨hal-01928504⟩
84 Consultations
124 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More