Metallic trans-(N-Heterocyclic Carbene)-Amine-Platinum Complexes and Uses Thereof for Treating Cancer - Archive ouverte HAL Accéder directement au contenu
Brevet Année : 2022

Metallic trans-(N-Heterocyclic Carbene)-Amine-Platinum Complexes and Uses Thereof for Treating Cancer

Résumé

The present invention concerns new bimetallic trans-(N-Heterocyclic Carbene)-amine-Pt(II) complexes, and uses thereof for treating cancer in particular in combination with radiotherapy or in combination with radiotherapy and any anticancer drug. The present invention also concerns monometallic (Amine)Platinum(II) N-Heterocyclic Carbene complexes for treating cancer in particular in combination with radiotherapy or in combination with radiotherapy and any anticancer drug. Combined therapy is often used in clinic due to the fact that some drugs can induce synergistic effects when used at their subtoxic concentrations, thereby reducing their secondary toxic effects. Radiotherapy, is one of the most used modality in clinic (in 50% of the cases) but suffers some limitations namely radioresistance of tumor cells and reactions in normal tissue around the tumor.

Domaines

Cancer
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Dates et versions

hal-03768252 , version 1 (02-09-2022)

Identifiants

  • HAL Id : hal-03768252 , version 1

Citer

Jean-François Betzer, Angela Marinetti, Sophie Bombard, Deepanjan Ghosh, Tao Jia. Metallic trans-(N-Heterocyclic Carbene)-Amine-Platinum Complexes and Uses Thereof for Treating Cancer. France, Patent n° : WO 2022/084325 A1. 2022. ⟨hal-03768252⟩
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