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Article Dans Une Revue Scientific Reports Année : 2022

3D transcranial Ultrasound Localization Microscopy for discrimination between ischemic and hemorrhagic stroke in early phase

Résumé

Early diagnosis is a critical part of the emergency care of cerebral hemorrhages and ischemia. A rapid and accurate diagnosis of strokes reduces the delays to appropriate treatments and a better functional recovery. Currently, CTscan and MRI are the gold standards with constraints of accessibility, availability, and possibly some contraindications. The development of Ultrasound Localization Microscopy (ULM) has enabled new perspectives to conventional transcranial ultrasound imaging with increased sensitivity, penetration depth, and resolution. The possibility of volumetric imaging has increased the field-of-view and provided a more precise description of the microvascularisation. In this study, rats (n=9) were subjected to thromboembolic ischemic stroke or intracerebral hemorrhages prior to volumetric ULM at the early phases after onsets. Although the volumetric ULM performed in the early phase of ischemic stroke revealed a large hypoperfused area in the cortical area of the occluded artery, it showed a more diffused hypoperfusion in the hemorrhagic model. Respective computations of a Microvascular Diffusion Index highlighted different patterns of perfusion loss during the first 24h of these two strokes' subtypes. Our study provides the first proof that this methodology should allow early discrimination between ischemic and hemorrhagic stroke with a potential toward diagnosis and monitoring in clinic.
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Commentaire : Ischemic stroke model in the rat before onset and 30 minutes after.
Format : Vidéo
Commentaire : Hemorrhagic stroke model in the rat before onset and one day after.

Dates et versions

hal-03765361 , version 1 (31-08-2022)

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Arthur Chavignon, Vincent Hingot, Cyrille Orset, Denis Vivien, Olivier Couture. 3D transcranial Ultrasound Localization Microscopy for discrimination between ischemic and hemorrhagic stroke in early phase. Scientific Reports, 2022, 12 (1), pp.14607. ⟨10.1038/s41598-022-18025-x⟩. ⟨hal-03765361⟩
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