Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]Isoquinolines - Archive ouverte HAL Access content directly
Journal Articles Molecules Year : 2022

Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]Isoquinolines

Abstract

A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was detrimental to Haspin inhibition, while the introduction of an alkyl group at the 4-position led to a modification of the kinase inhibition profiles. Altogether, the results obtained demonstrated that new pyrazolo[3,4-g]isoquinolines represent a novel family of kinase inhibitors with various selectivity profiles.

Dates and versions

hal-03765284 , version 1 (31-08-2022)

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Mathilde Defois, Chloé Rémondin, Béatrice Josselin, Lionel Nauton, Vincent Théry, et al.. Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]Isoquinolines. Molecules, 2022, 27 (17), pp.5578. ⟨10.3390/molecules27175578⟩. ⟨hal-03765284⟩
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