G1 Control in Yeast and Animal Cells - Archive ouverte HAL
Chapitre D'ouvrage Année : 2007

G1 Control in Yeast and Animal Cells

Résumé

In budding yeast, Saccharomyces cerevisiae, the cell cycle is controlled at the Gl/S phase transition by regulating the activity of the CDC28 protein kinase. This is the budding yeast homologue of the cdc2 protein kinase associated in most organisms with control of mitosis. In budding yeast CDC28 controls both the Gl/S phase transition and the G2/M phase transition by being differentially activated by two distinct classes of positive regulatory subunits known as G1 cyclins or CLNs and B-type cyclins or CLBs, respectively. To establish whether a similar dual role for Cdc2-related kinases exists in animal cells, we and others have sought human homologues of yeast G1 cyclins. Of several candidates, cyclin E is the most promising in that it accumulates prior to S phase and is associated with a pre-S phase protein kinase activity. The kinetics of accumulation of cyclin E-associated protein kinase activity is consistent with a role at the mammalian cell cycle restriction point.
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Dates et versions

hal-03763321 , version 1 (29-08-2022)

Identifiants

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Steven Reed, Vjekoslav Dulic, Daniel Lew, Helena Richardson, Curt Wittenberg. G1 Control in Yeast and Animal Cells. Ciba Foundation Symposium 170 - Regulation of the Eukaryotic Cell Cycle, John Wiley & Sons, Ltd., pp.7-19, 2007, Novartis Foundation Symposia, ⟨10.1002/9780470514320.ch2⟩. ⟨hal-03763321⟩
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