Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)
Å Olsson
(1)
,
Neela Guha
,
Liacine Bouaoun
(1)
,
Hans Kromhout
(2)
,
Susan Peters
(2)
,
Jack Siemiatycki
(3)
,
Vikki Ho
(3)
,
Per Gustavsson
(4)
,
Paolo Boffetta
(5, 6)
,
Roel Vermeulen
(2)
,
Thomas Behrens
(7)
,
Thomas Brüning
(7)
,
Benjamin Kendzia
(7)
,
Pascal Guénel
(8)
,
Danièle Luce
(9, 10)
,
Stefan Karrasch
(11)
,
H.-E. Wichmann
(11)
,
Dario Consonni
(12)
,
Maria Teresa Landi
(13)
,
Neil E Caporaso
(13)
,
Franco Merletti
(14)
,
Dario Mirabelli
(14)
,
Lorenzo Richiardi
(14)
,
Karl-Heinz Jöckel
(15)
,
Wolfgang Ahrens
(16)
,
Hermann Pohlabeln
(17)
,
Adonina Tardon
(18)
,
David Zaridze
(19)
,
Martin J Field
(20)
,
Jolanta Lissowska
(21)
,
Beata Swiatkowska
(22)
,
John R Mclaughlin
(23)
,
Paul A Demers
(24)
,
Vladimir Bencko
(25)
,
Lenka Foretova
(26)
,
Vladimír Janout
(27)
,
Tamás Pándics
(28)
,
Eleonóra Fabiánová
,
Dana Mates
(29)
,
Francesco Forastiere
(30)
,
H Bas Bueno-De-Mesquita
(31)
,
Joachim Schüz
(1)
,
Kurt Straif
(32, 33)
1
CIRC - IARC -
Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
2 Universiteit Utrecht / Utrecht University [Utrecht]
3 UdeM - Université de Montréal
4 Karolinska Institutet [Stockholm]
5 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
6 SBU - Stony Brook University [SUNY]
7 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
8 CESP - Centre de recherche en épidémiologie et santé des populations
9 Irset - Institut de recherche en santé, environnement et travail
10 EHESP - École des Hautes Études en Santé Publique [EHESP]
11 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
12 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
13 NCI-NIH - National Cancer Institute [Bethesda]
14 DMS - Department of Medical Sciences [Turin, Italy]
15 Uniklinik Essen - Universitätsklinikum Essen [Universität Duisburg-Essen]
16 Universität Bremen
17 Leibniz Institute for Prevention Research and Epidemiology - BIPS
18 Universidad de Oviedo = University of Oviedo
19 N.N. Blokhin National Medical Research Center of Oncology
20 University of Liverpool
21 MCMCC - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
22 NIOM - Nofer Institute of Occupational Medicine
23 University of Toronto
24 Occupational Cancer Research Centre
25 1. LF UK / 1st Faculty of Medicine - 1. lékařská fakulta, Univerzita Karlova [Praha, Česká republika] = First Faculty of Medicine, Charles University [Prague, Czech Republic]
26 MMCI - Masaryk Memorial Cancer Institute
27 Faculty of Health Sciences [UEF, Kuopio, Finland]
28 National Public Health Center
29 INSP - National Institute of Public Health [Romania]
30 ASL - Azienda Sanitaria Locale [ROMA]
31 RIVM - National Institute for Public Health and the Environment [Bilthoven]
32 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
33 BC - Boston College
2 Universiteit Utrecht / Utrecht University [Utrecht]
3 UdeM - Université de Montréal
4 Karolinska Institutet [Stockholm]
5 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
6 SBU - Stony Brook University [SUNY]
7 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
8 CESP - Centre de recherche en épidémiologie et santé des populations
9 Irset - Institut de recherche en santé, environnement et travail
10 EHESP - École des Hautes Études en Santé Publique [EHESP]
11 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
12 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
13 NCI-NIH - National Cancer Institute [Bethesda]
14 DMS - Department of Medical Sciences [Turin, Italy]
15 Uniklinik Essen - Universitätsklinikum Essen [Universität Duisburg-Essen]
16 Universität Bremen
17 Leibniz Institute for Prevention Research and Epidemiology - BIPS
18 Universidad de Oviedo = University of Oviedo
19 N.N. Blokhin National Medical Research Center of Oncology
20 University of Liverpool
21 MCMCC - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
22 NIOM - Nofer Institute of Occupational Medicine
23 University of Toronto
24 Occupational Cancer Research Centre
25 1. LF UK / 1st Faculty of Medicine - 1. lékařská fakulta, Univerzita Karlova [Praha, Česká republika] = First Faculty of Medicine, Charles University [Prague, Czech Republic]
26 MMCI - Masaryk Memorial Cancer Institute
27 Faculty of Health Sciences [UEF, Kuopio, Finland]
28 National Public Health Center
29 INSP - National Institute of Public Health [Romania]
30 ASL - Azienda Sanitaria Locale [ROMA]
31 RIVM - National Institute for Public Health and the Environment [Bilthoven]
32 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
33 BC - Boston College
Å Olsson
- Fonction : Auteur
- PersonId : 889278
Neela Guha
- Fonction : Auteur
Liacine Bouaoun
- Fonction : Auteur
- PersonId : 1119039
Hans Kromhout
- Fonction : Auteur
- PersonId : 846065
Susan Peters
- Fonction : Auteur
- PersonId : 773487
- ORCID : 0000-0001-5662-1971
Jack Siemiatycki
- Fonction : Auteur
- PersonId : 928704
- ORCID : 0000-0002-9042-8582
Paolo Boffetta
- Fonction : Auteur
- PersonId : 846063
Roel Vermeulen
- Fonction : Auteur
- PersonId : 924705
Thomas Behrens
- Fonction : Auteur
- PersonId : 972335
Pascal Guénel
- Fonction : Auteur
- PersonId : 757378
- ORCID : 0000-0002-8359-518X
- IdRef : 032371578
Danièle Luce
- Fonction : Auteur
- PersonId : 181336
- IdHAL : daniele-luce
- ORCID : 0000-0002-1708-4584
- IdRef : 097726745
Dario Consonni
- Fonction : Auteur
- PersonId : 899509
Karl-Heinz Jöckel
- Fonction : Auteur
- PersonId : 871911
Eleonóra Fabiánová
- Fonction : Auteur
Francesco Forastiere
- Fonction : Auteur
- PersonId : 773255
- ORCID : 0000-0002-9162-5684
- IdRef : 228520851
H Bas Bueno-De-Mesquita
- Fonction : Auteur
- PersonId : 908175
Joachim Schüz
- Fonction : Auteur
- PersonId : 929416
Kurt Straif
- Fonction : Auteur
- PersonId : 765183
- ORCID : 0000-0003-1402-2406
Résumé
BACKGROUND: Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project.
METHODS: We pooled 14 case-control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada. Exposure to benzo[a]pyrene (BaP) was used as a proxy of PAH and estimated from a quantitative general population job-exposure matrix. Multivariable unconditional logistic regression models, adjusted for smoking and exposure to other occupational lung carcinogens, estimated ORs, and 95% confidence intervals (CI).
RESULTS: We included 16,901 lung cancer cases and 20,965 frequency-matched controls. Adjusted OR for PAH exposure (ever) was 1.08 (CI, 1.02-1.15) in men and 1.20 (CI, 1.04-1.38) in women. When stratified by smoking status and histologic subtype, the OR for cumulative exposure ≥0.24 BaP μg/m3-years in men was higher in never smokers overall [1.31 (CI, 0.98-1.75)], for small cell [2.53 (CI, 1.28-4.99)] and squamous cell cancers [1.33 (CI, 0.80-2.21)]. Joint effects between PAH and smoking were observed. Restricting analysis to the most recent studies showed no increased risk.
CONCLUSIONS: Elevated lung cancer risk associated with PAH exposure was observed in both sexes, particularly for small cell and squamous cell cancers, after accounting for cigarette smoking and exposure to other occupational lung carcinogens. IMPACT: The lack of association between PAH and lung cancer in more recent studies merits further research under today’s exposure conditions and worker protection measures.
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