The Dynamical Systems Properties of the HOG Signaling Cascade - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Signal Transduction Année : 2011

The Dynamical Systems Properties of the HOG Signaling Cascade

Agnès Miermont
  • Fonction : Auteur
Jannis Uhlendorf
  • Fonction : Auteur
  • PersonId : 944326
  • IdRef : 170400239
Megan Mcclean
  • Fonction : Auteur
Pascal Hersen

Résumé

The High Osmolarity Glycerol (HOG) MAP kinase pathway in the budding yeast Saccharomyces cerevisiae is one of the best characterized model signaling pathways. The pathway processes external signals of increased osmolarity into appropriate physiological responses within the yeast cell. Recent advances in microfluidic technology coupled with quantitative modeling, and techniques from reverse systems engineering have allowed yet further insight into this already well-understood pathway. These new techniques are essential for understanding the dynamical processes at play when cells process external stimuli into biological responses. They are widely applicable to other signaling pathways of interest. Here, we review the recent advances brought by these approaches in the context of understanding the dynamics of the HOG pathway signaling.

Dates et versions

hal-03761696 , version 1 (26-08-2022)

Identifiants

Citer

Agnès Miermont, Jannis Uhlendorf, Megan Mcclean, Pascal Hersen. The Dynamical Systems Properties of the HOG Signaling Cascade. Journal of Signal Transduction, 2011, 2011, pp.1-12. ⟨10.1155/2011/930940⟩. ⟨hal-03761696⟩
7 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More