We study neutron star configurations in a simple shift-symmetric subfamily of degenerate higher-order scalar-tensor (DHOST) theories, whose deviations from General Relativity (GR) are characterized by a single parameter. We compute the radial profiles of neutron stars in these theories of modified gravity, using several realistic equations of state for the neutron star matter. We find neutron stars with masses and radii significantly larger than their GR counterparts. We then consider slowly-rotating solutions and determine the relation between the dimensionless moment of inertia and the compactness, relation that has the property to be almost insensitive to the equation of state.