<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03756697</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T07:25:55+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform</title>
            <author role="aut">
              <persName>
                <forename type="first">Christopher</forename>
                <surname>Chevillard</surname>
              </persName>
              <idno type="halauthorid">2313547-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Axelle</forename>
                <surname>Amen</surname>
              </persName>
              <idno type="idhal" notation="numeric">1319131</idno>
              <idno type="halauthorid" notation="string">2332342-1319131</idno>
              <idno type="IDREF">https://www.idref.fr/259938742</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0449-4445</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CBM-3777-2022</idno>
              <idno type="VIAF">https://viaf.org/viaf/110164476654925912422</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Solène</forename>
                <surname>Besson</surname>
              </persName>
              <idno type="halauthorid">2031920-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dalil</forename>
                <surname>Hannani</surname>
              </persName>
              <email type="md5">6b64828ba0d73d03bccaf7864898b4b4</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">dalil-hannani</idno>
              <idno type="idhal" notation="numeric">172900</idno>
              <idno type="halauthorid" notation="string">10691-172900</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5097-1401</idno>
              <idno type="IDREF">https://www.idref.fr/14571876X</idno>
              <affiliation ref="#struct-1069752"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Bally</surname>
              </persName>
              <idno type="idhal" notation="numeric">772477</idno>
              <idno type="halauthorid" notation="string">865069-772477</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8315-6080</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valentin</forename>
                <surname>Dettling</surname>
              </persName>
              <idno type="halauthorid">2313548-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Evelyne</forename>
                <surname>Gout</surname>
              </persName>
              <idno type="halauthorid">452819-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Moreau</surname>
              </persName>
              <email type="md5">242da98ed40688671598aeec1c5193ee</email>
              <email type="domain">ibs.fr</email>
              <idno type="idhal" notation="string">christophe-moreau</idno>
              <idno type="idhal" notation="numeric">739859</idno>
              <idno type="halauthorid" notation="string">377322-739859</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/D-3736-2009</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5463-9593</idno>
              <idno type="IDREF">https://www.idref.fr/065151194</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marlyse</forename>
                <surname>Buisson</surname>
              </persName>
              <idno type="halauthorid">917883-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Salomé</forename>
                <surname>Gallet</surname>
              </persName>
              <idno type="halauthorid">2232384-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daphna</forename>
                <surname>Fenel</surname>
              </persName>
              <idno type="halauthorid">910946-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emilie</forename>
                <surname>Vassal-Stermann</surname>
              </persName>
              <email type="md5">797fc5701e2197b93b3338ef44717aa5</email>
              <email type="domain">ibs.fr</email>
              <idno type="idhal" notation="string">emilie-stermann</idno>
              <idno type="idhal" notation="numeric">1344062</idno>
              <idno type="halauthorid" notation="string">739510-1344062</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8486-4935</idno>
              <idno type="IDREF">https://www.idref.fr/14022100X</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guy</forename>
                <surname>Schoehn</surname>
              </persName>
              <idno type="halauthorid">5827-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascal</forename>
                <surname>Poignard</surname>
              </persName>
              <idno type="halauthorid">305037-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Claire</forename>
                <surname>Dagher</surname>
              </persName>
              <idno type="halauthorid">387752-0</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascal</forename>
                <surname>Fender</surname>
              </persName>
              <email type="md5">61e0f20f56e6d0e04b9e19e2eeaeda59</email>
              <email type="domain">ibs.fr</email>
              <idno type="idhal" notation="string">pascal-fender</idno>
              <idno type="idhal" notation="numeric">12905</idno>
              <idno type="halauthorid" notation="string">24033-12905</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6698-3367</idno>
              <idno type="IDREF">https://www.idref.fr/070009627</idno>
              <idno type="IDREF">https://www.idref.fr/16549140X</idno>
              <affiliation ref="#struct-1043235"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Frank</forename>
                <surname>Thomas</surname>
              </persName>
              <email type="md5">d93af13e6932f3e24cc9a230ad329114</email>
              <email type="domain">ibs.fr</email>
            </editor>
            <funder ref="#projanr-50259"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-08-22 12:50:40</date>
              <date type="whenModified">2026-02-26 16:49:45</date>
              <date type="whenReleased">2022-08-23 14:51:51</date>
              <date type="whenProduced">2022-05-04</date>
              <date type="whenEndEmbargoed">2022-08-22</date>
              <ref type="file" target="https://hal.science/hal-03756697v1/document">
                <date notBefore="2022-08-22"/>
              </ref>
              <ref type="file" subtype="publisherAgreement" n="1" target="https://hal.science/hal-03756697v1/file/Chevillard%20et%20al.%20Mol%20Ther.pdf" id="file-3756728-3283589">
                <date notBefore="2022-08-22"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828441"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="139172">
                <persName>
                  <forename>Frank</forename>
                  <surname>Thomas</surname>
                </persName>
                <email type="md5">d93af13e6932f3e24cc9a230ad329114</email>
                <email type="domain">ibs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03756697</idno>
            <idno type="halUri">https://hal.science/hal-03756697</idno>
            <idno type="halBibtex">chevillard:hal-03756697</idno>
            <idno type="halRefHtml">&lt;i&gt;Molecular Therapy&lt;/i&gt;, 2022, 30 (5), pp.1913-1925. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ymthe.2022.02.011"&gt;&amp;#x27E8;10.1016/j.ymthe.2022.02.011&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Molecular Therapy, 2022, 30 (5), pp.1913-1925. &amp;#x27E8;10.1016/j.ymthe.2022.02.011&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3756728-3283589"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="IBS" corresp="CEA">Institut de Biologie Structurale</idno>
            <idno type="stamp" n="IBS-SAG" corresp="IBS">Groupe Structure et Activité des Glycosaminoglycanes / Structure and Activity of Glycosaminoglycans Group (IBS-SAGAG)</idno>
            <idno type="stamp" n="IBS-TME" corresp="IBS">Groupe Transporteurs Membranaires / Membrane Transporters Group (IBS-MEMBRANE)</idno>
            <idno type="stamp" n="IBS-MEM" corresp="IBS">Groupe Microscopie Electronique et Méthodes / Methods and Electron Microscopy Group (IBS-MEM)</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="IRIG" corresp="CEA">Institut de Recherche Interdisciplinaire de Grenoble</idno>
            <idno type="stamp" n="CEA-GRE" corresp="CEA">CEA Grenoble</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="IBS-CAID" corresp="IBS">Groupe Complément, anticorps et maladies infectieuses / Complement, antibodies and infectious disease Group (IBS-CAID)</idno>
            <idno type="stamp" n="TIMC-TREE" corresp="TIMC-IMAG">TrEE : Translational microbial Evolution and Engineering</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Christopher</forename>
                    <surname>Chevillard</surname>
                  </persName>
                  <idno type="halauthorid">2313547-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Axelle</forename>
                    <surname>Amen</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1319131</idno>
                  <idno type="halauthorid" notation="string">2332342-1319131</idno>
                  <idno type="IDREF">https://www.idref.fr/259938742</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0449-4445</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CBM-3777-2022</idno>
                  <idno type="VIAF">https://viaf.org/viaf/110164476654925912422</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Solène</forename>
                    <surname>Besson</surname>
                  </persName>
                  <idno type="halauthorid">2031920-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dalil</forename>
                    <surname>Hannani</surname>
                  </persName>
                  <email type="md5">6b64828ba0d73d03bccaf7864898b4b4</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">dalil-hannani</idno>
                  <idno type="idhal" notation="numeric">172900</idno>
                  <idno type="halauthorid" notation="string">10691-172900</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5097-1401</idno>
                  <idno type="IDREF">https://www.idref.fr/14571876X</idno>
                  <affiliation ref="#struct-1069752"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Bally</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">772477</idno>
                  <idno type="halauthorid" notation="string">865069-772477</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8315-6080</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valentin</forename>
                    <surname>Dettling</surname>
                  </persName>
                  <idno type="halauthorid">2313548-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Evelyne</forename>
                    <surname>Gout</surname>
                  </persName>
                  <idno type="halauthorid">452819-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Moreau</surname>
                  </persName>
                  <email type="md5">242da98ed40688671598aeec1c5193ee</email>
                  <email type="domain">ibs.fr</email>
                  <idno type="idhal" notation="string">christophe-moreau</idno>
                  <idno type="idhal" notation="numeric">739859</idno>
                  <idno type="halauthorid" notation="string">377322-739859</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/D-3736-2009</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5463-9593</idno>
                  <idno type="IDREF">https://www.idref.fr/065151194</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marlyse</forename>
                    <surname>Buisson</surname>
                  </persName>
                  <idno type="halauthorid">917883-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Salomé</forename>
                    <surname>Gallet</surname>
                  </persName>
                  <idno type="halauthorid">2232384-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daphna</forename>
                    <surname>Fenel</surname>
                  </persName>
                  <idno type="halauthorid">910946-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emilie</forename>
                    <surname>Vassal-Stermann</surname>
                  </persName>
                  <email type="md5">797fc5701e2197b93b3338ef44717aa5</email>
                  <email type="domain">ibs.fr</email>
                  <idno type="idhal" notation="string">emilie-stermann</idno>
                  <idno type="idhal" notation="numeric">1344062</idno>
                  <idno type="halauthorid" notation="string">739510-1344062</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8486-4935</idno>
                  <idno type="IDREF">https://www.idref.fr/14022100X</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guy</forename>
                    <surname>Schoehn</surname>
                  </persName>
                  <idno type="halauthorid">5827-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascal</forename>
                    <surname>Poignard</surname>
                  </persName>
                  <idno type="halauthorid">305037-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Claire</forename>
                    <surname>Dagher</surname>
                  </persName>
                  <idno type="halauthorid">387752-0</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascal</forename>
                    <surname>Fender</surname>
                  </persName>
                  <email type="md5">61e0f20f56e6d0e04b9e19e2eeaeda59</email>
                  <email type="domain">ibs.fr</email>
                  <idno type="idhal" notation="string">pascal-fender</idno>
                  <idno type="idhal" notation="numeric">12905</idno>
                  <idno type="halauthorid" notation="string">24033-12905</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6698-3367</idno>
                  <idno type="IDREF">https://www.idref.fr/070009627</idno>
                  <idno type="IDREF">https://www.idref.fr/16549140X</idno>
                  <affiliation ref="#struct-1043235"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17194</idno>
                <idno type="issn">1525-0016</idno>
                <idno type="eissn">1525-0024</idno>
                <title level="j">Molecular Therapy</title>
                <imprint>
                  <publisher>Cell Press</publisher>
                  <biblScope unit="volume">30</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">1913-1925</biblScope>
                  <date type="datePub">2022-05-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ymthe.2022.02.011</idno>
              <idno type="pubmed">35151843</idno>
              <idno type="pubmedcentral">PMC8828441</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Vaccine platform</term>
                <term xml:lang="en">SARS-CoV-2</term>
                <term xml:lang="en">Virus-like particle</term>
                <term xml:lang="en">Adenovirus</term>
                <term xml:lang="en">Antigen display</term>
                <term xml:lang="en">COVID-19</term>
                <term xml:lang="en">Neutralizing antibodies</term>
                <term xml:lang="en">Receptor-binding domain</term>
              </keywords>
              <classCode scheme="mesh">Adenoviridae</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Mice</classCode>
              <classCode scheme="mesh">SARS-CoV-2</classCode>
              <classCode scheme="mesh">Vaccination</classCode>
              <classCode scheme="mesh">Antibodies, Neutralizing</classCode>
              <classCode scheme="mesh">Antibodies, Viral</classCode>
              <classCode scheme="mesh">COVID-19</classCode>
              <classCode scheme="mesh">COVID-19 Vaccines</classCode>
              <classCode scheme="mesh">Cryoelectron Microscopy</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bs">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Virus-like particles (VLPs) are highly suited platforms for protein-based vaccines. In the present work, we adapted a previously designed non-infectious adenovirus-inspired 60-mer dodecahedric VLP (ADDomer) to display a multimeric array of large antigens through a SpyTag/SpyCatcher system. To validate the platform as a potential COVID-19 vaccine approach, we decorated the newly designed VLP with the glycosylated receptor binding domain (RBD) of SARS-CoV-2. Cryoelectron microscopy structure revealed that up to 60 copies of this antigenic domain could be bound on a single ADDomer particle, with the symmetrical arrangements of a dodecahedron. Mouse immunization with the RBD decorated VLPs already showed a significant specific humoral response following prime vaccination, greatly reinforced by a single boost. Neutralization assays with SARS-CoV-2 spike pseudo-typed virus demonstrated the elicitation of strong neutralization titers, superior to those of COVID-19 convalescent patients. Notably, the presence of pre-existing immunity against the adenoviral-derived particles did not hamper the immune response against the antigen displayed on its surface. This plug and play vaccine platform represents a promising new highly versatile tool to combat emergent pathogens.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="department" xml:id="struct-1043235" status="VALID">
          <idno type="IdRef">06912633X</idno>
          <idno type="ISNI">0000 0004 0641 5776</idno>
          <idno type="RNSR">199911764W</idno>
          <idno type="ROR">https://ror.org/04szabx38</idno>
          <orgName>Institut de biologie structurale</orgName>
          <orgName type="acronym">IBS - UMR 5075</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Institut de Biologie Structurale, 71 avenue des martyrs, CS 10090, 38044 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ibs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR5075" active="#struct-441569" type="direct"/>
            <relation name="DRF/IRIG/DBSC" active="#struct-555292" type="direct"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1069752" status="VALID">
          <orgName>Translational microbial Evolution and Engineering</orgName>
          <orgName type="acronym">TIMC-TrEE</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine de Grenoble, bâtiment Jean Roget, 38706 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/TrEE</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043049" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-555292" status="VALID">
          <idno type="IdRef">240648846</idno>
          <idno type="RNSR">201923169F</idno>
          <idno type="ROR">https://ror.org/00byxdz40</idno>
          <idno type="Wikidata">Q108737333</idno>
          <orgName>Institut de Recherche Interdisciplinaire de Grenoble</orgName>
          <orgName type="acronym">IRIG</orgName>
          <date type="start">2019-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://hal-cea.archives-ouvertes.fr/IRIG/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/IRIG" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50259" status="VALID">
          <idno type="anr">ANR-17-EURE-0003</idno>
          <orgName>CBH-EUR-GS</orgName>
          <desc>CBH-EUR-GS</desc>
          <date type="start">2017</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>