Comment on Three Papers about Hardy-Weinberg Equilibrium Tests in Autopolyploids
Résumé
Three similar manuscripts, by many of the same authors, were recently published describing methods for Hardy-Weinberg equilibrium and random mating testing in autotetraploids [Sun, et al. Trends in Genetics, 37(6), 2021. doi:10.1016/j.tig.2020.11.006], autohexaploids [Wang, et al. Horticulture Research, 9, 2022. doi:10.1093/hr/uhac104], and autooctoploids [Wang, et al. Frontiers in Genetics, 12, 2021. doi:10.3389/fgene.2021.794907]. We found issues with these manuscripts, which we detail here. The main problems that we see are (i) extensive mistakes and implementation errors, (ii) confusion between random mating and equilibrium, (iii) confusion between allo- and autopolyploid inheritance, and (iv) poor hypothesis testing approaches. We provide examples and simulations when appropriate. All of our results are open and reproducible.
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