Long-Term Functional Outcomes of an Anorectal Malformation French National Cohort - Archive ouverte HAL
Article Dans Une Revue Journal of Pediatric Gastroenterology and Nutrition Année : 2022

Long-Term Functional Outcomes of an Anorectal Malformation French National Cohort

1 CHU Angers - Centre Hospitalier Universitaire d'Angers
2 HIFIH - Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques
3 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
4 HFME - Hôpital Femme Mère Enfant [CHU - HCL]
5 HCL - Hospices Civils de Lyon
6 TIMONE - Hôpital de la Timone [CHU - APHM]
7 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
8 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
9 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
10 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
11 CHU Trousseau [APHP]
12 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
13 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
14 CHU Amiens-Picardie
15 Service de Pédiatrie médicale [CHU Limoges]
16 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
17 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
18 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
19 CH Saint-Brieuc - Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll]
20 Hôpital Necker - Enfants Malades [AP-HP]
21 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
22 Département Chirurgie Pédiatrique [CHRU Montpellier]
23 IDESP - Institut Desbrest de santé publique
24 CHU Trousseau [Tours]
25 CH Colmar
26 CHU de la Martinique [Fort de France]
27 Centre Hospitalier Le Mans (CH Le Mans)
28 CHRO - Centre Hospitalier Régional d'Orléans
29 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
30 CHU Reims - Hôpital universitaire Robert Debré [Reims]
31 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
Sabine Irtan
  • Fonction : Auteur
  • PersonId : 983127
Sandy Jochault-Ritz
  • Fonction : Auteur
Emmanuel Sapin
  • Fonction : Auteur
  • PersonId : 885142

Résumé

Objectives: The present study aimed to assess long-term functional outcomes of children with anorectal malformations (ARMs) across a network of expert centers in France. Methods: Retrospective cross-sectional study of patients ages 6-30 years that had been surgically treated for ARM. Patient and ARM characteristics (eg, level, surgical approach) and functional outcomes were assessed in the different age groups. Results: Among 367 patients, there were 155 females (42.2%) and 212 males (57.8%), 188 (51.2%) cases with, and 179 (48.8%) higher forms without, perineal fistula. Univariate and multivariate statistical analyses with logistic regression showed correlation between the level of the rectal blind pouch and voluntary bowel movements (odds ratio [OR] = 1.84 [1.31-2.57], P < 0.001), or soiling (OR = 1.72 [1.31-2.25], P < 0.001), which was also associated with the inability to discriminate between stool and gas (OR = 2.45 [1.28-4.67], P = 0.007) and the presence of constipation (OR = 2.97 [1.74-5.08], P < 0.001). Risk factors for constipation were sacral abnormalities [OR = 2.26 [1.23-4.25], P = 0.01) and surgical procedures without an abdominal approach (OR = 2.98 [1.29-6.87], P = 0.01). Only the holding of voluntary bowel movements and soiling rates improved with age. Conclusion: This cross-sectional study confirms a strong association between anatomical status and functional outcomes in patients surgically treated for ARM. It specifically highlights the need for long-term follow-up of all patients to help them with supportive care.
Fichier principal
Vignette du fichier
PMID 35849503.pdf (742.45 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-03741894 , version 1 (28-07-2023)

Licence

Identifiants

Citer

Françoise Schmitt, Aurélien Scalabre, Pierre-Yves Mure, Claude Borrione, Jean-Louis Lemelle, et al.. Long-Term Functional Outcomes of an Anorectal Malformation French National Cohort. Journal of Pediatric Gastroenterology and Nutrition, 2022, 74 (6), pp.782-787. ⟨10.1097/MPG.0000000000003447⟩. ⟨hal-03741894⟩
123 Consultations
129 Téléchargements

Altmetric

Partager

More