Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2012

Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway

Résumé

Although West Nile virus (WNV) and other arthropod-borne viruses are a major public health problem, the mechanisms of antiviral immunity in mosquitoes are poorly understood. Dicer-2, responsible for the RNAi-mediated response through the C-terminal RNase-III domain, also contains an N-terminal DExD/H-box helicase domain similar to mammalian RIG-I/MDA5 which, in Drosophila , was found to be required for activation of an antiviral gene, Vago . Here we show that the Culex orthologue of Vago ( Cx Vago) is up-regulated in response to WNV infection in a Dicer-2–dependent manner. Further, our data show that Cx Vago is a secreted peptide that restricts WNV infection by activation of the Jak-STAT pathway. Thus, Vago appears to function as an IFN-like antiviral cytokine in mosquitoes.

Dates et versions

hal-03736852 , version 1 (22-07-2022)

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Citer

Prasad N. Paradkar, Lee Trinidad, Rhonda Voysey, Jean-Bernard Duchemin, Peter J. Walker. Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (46), pp.18915-18920. ⟨10.1073/pnas.1205231109⟩. ⟨hal-03736852⟩
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