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            <funder>This work was supported by NASA’s Planetary Astronomy and Planetary Atmospheres Programs (SNM and SBC), and by the Swedish Space Board (ESW).</funder>
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                <term xml:lang="en">Comets</term>
                <term xml:lang="en">Isotopes</term>
                <term xml:lang="en">Interplanatary dust particules</term>
                <term xml:lang="en">O1 Hale-bopp</term>
                <term xml:lang="en">Low-Mass</term>
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              <p>Isotopic ratios in comets provide keys for the understanding of the origin of cometary material, and the physical and chemical conditions in the early Solar Nebula. We review here measurements acquired on the D/H, N-14/N-15, O-16/O-18, C-12/C-13, and S-32/S-34 ratios in cometary grains and gases, and discuss their cosmogonic implications. The review includes analyses of potential cometary material available in collections on Earth, recent measurements achieved with the Herschel Space Observatory, large optical telescopes, and Rosetta, as well as recent results obtained from models of chemical-dynamical deuterium fractionation in the early solar nebula. Prospects for future measurements are presented.</p>
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