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Journal Articles Journal of Parkinson's disease Year : 2022

Heterogeneity of PD-MCI in candidates to subthalamic deep brain stimulation: associated cortical and subcortical modifications

1 LilNCog - Lille Neurosciences & Cognition - U 1172
2 CHU Lille
3 PLBS - Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41
4 CENIR - Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
5 ICM - Institut du Cerveau = Paris Brain Institute
6 Hôpital Pellegrin
7 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
8 Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP]
9 BAOBAB - Building large instruments for neuroimaging: from population imaging to ultra-high magnetic fields
10 TIMONE - Hôpital de la Timone [CHU - APHM]
11 INT - Institut de Neurosciences de la Timone
12 CHU Poitiers - Centre hospitalier universitaire de Poitiers
13 CIC - Poitiers
14 Service de Neurologie [CHU Nice]
15 CHU Pitié-Salpêtrière [AP-HP]
16 SU FM - Sorbonne Université - Faculté de Médecine
17 Centre Hospitalier Universitaire [Rennes]
19 Hôpital Foch [Suresnes]
20 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
21 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
22 DC2N - Différenciation et communication neuronale et neuroendocrine
23 CHU Rouen
24 IP - Institut Pascal
25 INP Clermont Auvergne - Institut national polytechnique Clermont Auvergne
26 CHU Clermont-Ferrand
27 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
28 CHU Nantes - Centre hospitalier universitaire de Nantes
29 CHU Amiens-Picardie
30 Les Hôpitaux Universitaires de Strasbourg (HUS)
31 FMTS - Fédération de Médecine Translationnelle de Strasbourg
32 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
Marie Bonnet
  • Function : Author
Melissa Tir


Background: Parkinson’s disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes. Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups. Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels. Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes. Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia.
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Dates and versions

hal-03720928 , version 1 (12-07-2022)



Quentin Devignes, Sami Daoudi, Romain Viard, Renaud Lopes, Nacim Betrouni, et al.. Heterogeneity of PD-MCI in candidates to subthalamic deep brain stimulation: associated cortical and subcortical modifications. Journal of Parkinson's disease, 2022, 12 (5), pp.1507-1526. ⟨10.3233/JPD-223232⟩. ⟨hal-03720928⟩
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