Targeting Redox Metabolism in Pancreatic Cancer - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2021

Targeting Redox Metabolism in Pancreatic Cancer

Résumé

Cell metabolism is reprogrammed in cancer cells to meet their high bioenergetics and biosynthetic demands. This metabolic reprogramming is accompanied by alterations in redox metabolism, characterized by accumulation of reactive oxygen species (ROS). Elevated production of ROS, mostly by mitochondrial respiration, is counteracted by higher production of antioxidant defenses (mainly glutathione and antioxidant enzymes). Cancer cells are adapted to a high concentration of ROS, which contributes to tumorigenesis, metastasis formation, resistance to therapy and relapse. Frequent genetic alterations observed in pancreatic ductal adenocarcinoma (PDAC) affect KRAS and p53 proteins, which have a role in ROS production and control, respectively. These observations led to the proposal of the use of antioxidants to prevent PDAC development and relapse. In this review, we focus on the therapeutic strategies to further increase ROS level to induce PDAC cell death. Combining the promotion of ROS production and inhibition of antioxidant capacity is a promising avenue for pancreatic cancer therapy in the clinic.
Fichier principal
Vignette du fichier
Abdel Hadi-IJMS 2021 (Review).pdf (1.3 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03716453 , version 1 (07-07-2022)

Licence

Identifiants

Citer

Nadine Abdel Hadi, Gabriela Reyes-Castellanos, Alice Carrier. Targeting Redox Metabolism in Pancreatic Cancer. International Journal of Molecular Sciences, 2021, 22 (4), pp.1534. ⟨10.3390/ijms22041534⟩. ⟨hal-03716453⟩
42 Consultations
72 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More