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Journal Articles Genes and Development Year : 2022

Endothelial cells give a boost to senescence surveillance

Abstract

Senescence is a specialized form of cell cycle arrest induced in response to damage and stress. In certain settings, senescent cells can promote their own removal by recruitment of the immune system, a process that is thought to decline in efficiency with age. In this issue of Genes & Development , Yin et al. (pp. 533–549) discover a surprising cross-talk where senescent cells instruct endothelial cells to help organize the clearance of the senescent population. This uncovers yet another layer of complexity in senescent cell biology, with implications for cancer treatment and aging.
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Dates and versions

hal-03715500 , version 1 (26-09-2023)

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Daniel Sampaio Gonçalves, William M Keyes. Endothelial cells give a boost to senescence surveillance. Genes and Development, 2022, 36 (9-10), pp.511-513. ⟨10.1101/gad.349767.122⟩. ⟨hal-03715500⟩
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