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Chapitre D'ouvrage Année : 2012

Persistent Luminescence Nanoparticles for Bioimaging

Cyrille Richard
Thomas Maldiney
  • Fonction : Auteur
Quentin Le Masne de Chermont
  • Fonction : Auteur
Johanne Seguin
Nicolas Wattier
  • Fonction : Auteur
Gabriel Courties
  • Fonction : Auteur
Michel Bessodes
  • Fonction : Auteur
Daniel Scherman
  • Fonction : Auteur

Résumé

Optical imaging is a rapidly developing field of research aimed at noninvasive monitoring of disease progression, evaluating the effects and pharmacokinetic of a drug, or identifying pathological biomarkers. To this end, it requires the development of targeting and highly specific contrast agents. In fluorescence imaging, an external light of appropriate wavelength is used to excite the fluorescent molecule, followed almost immediately by the release of longer wavelength, lower energy light for imaging. Fluorescence is increasingly used for imaging and has provided remarkable results. However this technique presents several limitations, especially due to tissue autofluorescence under external illumination and weak tissue penetration of low wavelength excitation light. To overcome these drawbacks, we have developed an innovative technique using persistent luminescence nanoparticles (PLNP) for optical imaging in small animal. Such nanoparticles can be excited before systemic injection, and their biodistribution monitored in real-time for dozen of minutes without the need for any external illumination source. This review article will focus on recent works undertaken in our laboratory on the synthesis of PLNP, their surface modifications and applications for bioimaging.
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Dates et versions

hal-03714607 , version 1 (05-07-2022)

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  • HAL Id : hal-03714607 , version 1

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Cyrille Richard, Thomas Maldiney, Quentin Le Masne de Chermont, Johanne Seguin, Nicolas Wattier, et al.. Persistent Luminescence Nanoparticles for Bioimaging. From Physics to Signal Understanding Issues, 2012. ⟨hal-03714607⟩
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