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Article Dans Une Revue Biomolecules Année : 2022

Cytoplasmic and Nuclear Functions of cIAP1

Résumé

Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some cytokine receptors and pattern recognition-receptors (PRRs). Although less documented, cIAP1 has also been involved in the regulation of cell migration and in the control of transcriptional programs.
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Dates et versions

hal-03707070 , version 1 (28-06-2022)

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Aymeric Zadoroznyj, Laurence Dubrez. Cytoplasmic and Nuclear Functions of cIAP1. Biomolecules, 2022, 12 (2), pp.322. ⟨10.3390/biom12020322⟩. ⟨hal-03707070⟩
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