<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03704369</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T14:57:31+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Application of the OMERACT synovitis ultrasound scoring system in juvenile idiopathic arthritis: a multicenter reliability exercise</title>
            <author role="aut">
              <persName>
                <forename type="first">Linda</forename>
                <surname>Rossi-Semerano</surname>
              </persName>
              <idno type="halauthorid">680657-0</idno>
              <affiliation ref="#struct-1003702"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvain</forename>
                <surname>Breton</surname>
              </persName>
              <idno type="halauthorid">685089-0</idno>
              <affiliation ref="#struct-414766"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luca</forename>
                <surname>Semerano</surname>
              </persName>
              <idno type="halauthorid">820946-0</idno>
              <affiliation ref="#struct-300210"/>
              <affiliation ref="#struct-1001049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marouane</forename>
                <surname>Boubaya</surname>
              </persName>
              <idno type="halauthorid">820948-0</idno>
              <affiliation ref="#struct-300210"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Haykanush</forename>
                <surname>Ohanyan</surname>
              </persName>
              <idno type="halauthorid">1599523-0</idno>
              <affiliation ref="#struct-300153"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Bossert</surname>
              </persName>
              <idno type="halauthorid">447986-0</idno>
              <affiliation ref="#struct-475859"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sorina</forename>
                <surname>Boiu</surname>
              </persName>
              <idno type="halauthorid">2120884-0</idno>
              <affiliation ref="#struct-494389"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuel</forename>
                <surname>Chatelus</surname>
              </persName>
              <email type="md5">cbe937abe2c014191dbd9c34885eeaf7</email>
              <email type="domain">chru-strasbourg.fr</email>
              <idno type="idhal" notation="numeric">1131883</idno>
              <idno type="halauthorid" notation="string">529488-1131883</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7360-6527</idno>
              <idno type="IDREF">https://www.idref.fr/110777069</idno>
              <idno type="VIAF">https://viaf.org/viaf/212026651</idno>
              <idno type="ISNI">http://isni.org/isni/000000035871958X</idno>
              <affiliation ref="#struct-211628"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Géraldine</forename>
                <surname>Durand</surname>
              </persName>
              <idno type="halauthorid">744046-0</idno>
              <affiliation ref="#struct-300449"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Jean</surname>
              </persName>
              <idno type="halauthorid">488692-0</idno>
              <affiliation ref="#struct-542281"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurence</forename>
                <surname>Goumy</surname>
              </persName>
              <idno type="halauthorid">1477448-0</idno>
              <affiliation ref="#struct-151939"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Mathiot</surname>
              </persName>
              <idno type="halauthorid">2120885-0</idno>
              <affiliation ref="#struct-204321"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gaël</forename>
                <surname>Mouterde</surname>
              </persName>
              <email type="md5">8fea590c2d6abb2244cd531082568f99</email>
              <email type="domain">chu-montpellier.fr</email>
              <idno type="idhal" notation="string">gael-mouterde</idno>
              <idno type="idhal" notation="numeric">1144810</idno>
              <idno type="halauthorid" notation="string">466413-1144810</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0651-5035</idno>
              <affiliation ref="#struct-14059"/>
              <affiliation ref="#struct-1062542"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frédérique</forename>
                <surname>Nugues</surname>
              </persName>
              <idno type="halauthorid">490971-0</idno>
              <affiliation ref="#struct-535102"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ahmed</forename>
                <surname>Ould Hennia</surname>
              </persName>
              <idno type="halauthorid">2120886-0</idno>
              <affiliation ref="#struct-442527"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bénédicte</forename>
                <surname>Rey</surname>
              </persName>
              <idno type="halauthorid">1018062-0</idno>
              <affiliation ref="#struct-205059"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Annette</forename>
                <surname>von Scheven</surname>
              </persName>
              <idno type="halauthorid">2120887-0</idno>
              <affiliation ref="#struct-329903"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laetitia</forename>
                <surname>Sparsa</surname>
              </persName>
              <idno type="halauthorid">2120888-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Valérie</forename>
                <surname>Devauchelle-Pensec</surname>
              </persName>
              <idno type="halauthorid">658544-0</idno>
              <affiliation ref="#struct-486351"/>
              <affiliation ref="#struct-454221"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sandrine</forename>
                <surname>Jousse-Joulin</surname>
              </persName>
              <idno type="halauthorid">658509-0</idno>
              <affiliation ref="#struct-486351"/>
              <affiliation ref="#struct-412239"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Gaël</forename>
                <surname>Mouterde</surname>
              </persName>
              <email type="md5">8fea590c2d6abb2244cd531082568f99</email>
              <email type="domain">chu-montpellier.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-06-24 19:12:44</date>
              <date type="whenModified">2026-05-06 17:18:05</date>
              <date type="whenReleased">2022-06-24 19:12:45</date>
              <date type="whenProduced">2021-08-01</date>
              <ref type="externalLink" target="https://research.vumc.nl/en/publications/a300e9f5-0c89-4605-b782-880993c7c2c3"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1298131">
                <persName>
                  <forename>Gaël</forename>
                  <surname>Mouterde</surname>
                </persName>
                <email type="md5">8fea590c2d6abb2244cd531082568f99</email>
                <email type="domain">chu-montpellier.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03704369</idno>
            <idno type="halUri">https://hal.science/hal-03704369</idno>
            <idno type="halBibtex">rossisemerano:hal-03704369</idno>
            <idno type="halRefHtml">&lt;i&gt;Rheumatology&lt;/i&gt;, 2021, 60 (8), pp.3579-3587. &lt;a target="_blank" href="https://dx.doi.org/10.1093/rheumatology/keaa804"&gt;&amp;#x27E8;10.1093/rheumatology/keaa804&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Rheumatology, 2021, 60 (8), pp.3579-3587. &amp;#x27E8;10.1093/rheumatology/keaa804&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-BREST">Université de Bretagne occidentale - Brest (UBO)</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="IMMUNO" corresp="UNIV-BREST">Lymphocyte B et Auto-immunité, UMR 1227</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno>
            <idno type="stamp" n="IBSAM" corresp="UNIV-BREST">Institut Brestois Santé Agro Matière</idno>
            <idno type="stamp" n="IBHGC" corresp="UNIV-PARIS13">Institut de Biomécanique Humaine Georges Charpak</idno>
            <idno type="stamp" n="LI2P" corresp="UNIV-PARIS13">Physiopathologie, cibles et thérapies de la polyarthrite rhumatoïde</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="IDESP">Institut Desbrest d’Épidémiologie et de Santé Publique</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="UM-EPE" corresp="UNIV-MONTPELLIER">Université de Montpellier - EPE</idno>
            <idno type="stamp" n="ACT-R" corresp="UNIV-PARIS13">Act'R </idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Application of the OMERACT synovitis ultrasound scoring system in juvenile idiopathic arthritis: a multicenter reliability exercise</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Linda</forename>
                    <surname>Rossi-Semerano</surname>
                  </persName>
                  <idno type="halauthorid">680657-0</idno>
                  <affiliation ref="#struct-1003702"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvain</forename>
                    <surname>Breton</surname>
                  </persName>
                  <idno type="halauthorid">685089-0</idno>
                  <affiliation ref="#struct-414766"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luca</forename>
                    <surname>Semerano</surname>
                  </persName>
                  <idno type="halauthorid">820946-0</idno>
                  <affiliation ref="#struct-300210"/>
                  <affiliation ref="#struct-1001049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marouane</forename>
                    <surname>Boubaya</surname>
                  </persName>
                  <idno type="halauthorid">820948-0</idno>
                  <affiliation ref="#struct-300210"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Haykanush</forename>
                    <surname>Ohanyan</surname>
                  </persName>
                  <idno type="halauthorid">1599523-0</idno>
                  <affiliation ref="#struct-300153"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Bossert</surname>
                  </persName>
                  <idno type="halauthorid">447986-0</idno>
                  <affiliation ref="#struct-475859"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sorina</forename>
                    <surname>Boiu</surname>
                  </persName>
                  <idno type="halauthorid">2120884-0</idno>
                  <affiliation ref="#struct-494389"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuel</forename>
                    <surname>Chatelus</surname>
                  </persName>
                  <email type="md5">cbe937abe2c014191dbd9c34885eeaf7</email>
                  <email type="domain">chru-strasbourg.fr</email>
                  <idno type="idhal" notation="numeric">1131883</idno>
                  <idno type="halauthorid" notation="string">529488-1131883</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7360-6527</idno>
                  <idno type="IDREF">https://www.idref.fr/110777069</idno>
                  <idno type="VIAF">https://viaf.org/viaf/212026651</idno>
                  <idno type="ISNI">http://isni.org/isni/000000035871958X</idno>
                  <affiliation ref="#struct-211628"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Géraldine</forename>
                    <surname>Durand</surname>
                  </persName>
                  <idno type="halauthorid">744046-0</idno>
                  <affiliation ref="#struct-300449"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Jean</surname>
                  </persName>
                  <idno type="halauthorid">488692-0</idno>
                  <affiliation ref="#struct-542281"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurence</forename>
                    <surname>Goumy</surname>
                  </persName>
                  <idno type="halauthorid">1477448-0</idno>
                  <affiliation ref="#struct-151939"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Mathiot</surname>
                  </persName>
                  <idno type="halauthorid">2120885-0</idno>
                  <affiliation ref="#struct-204321"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gaël</forename>
                    <surname>Mouterde</surname>
                  </persName>
                  <email type="md5">8fea590c2d6abb2244cd531082568f99</email>
                  <email type="domain">chu-montpellier.fr</email>
                  <idno type="idhal" notation="string">gael-mouterde</idno>
                  <idno type="idhal" notation="numeric">1144810</idno>
                  <idno type="halauthorid" notation="string">466413-1144810</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0651-5035</idno>
                  <affiliation ref="#struct-14059"/>
                  <affiliation ref="#struct-1062542"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frédérique</forename>
                    <surname>Nugues</surname>
                  </persName>
                  <idno type="halauthorid">490971-0</idno>
                  <affiliation ref="#struct-535102"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ahmed</forename>
                    <surname>Ould Hennia</surname>
                  </persName>
                  <idno type="halauthorid">2120886-0</idno>
                  <affiliation ref="#struct-442527"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bénédicte</forename>
                    <surname>Rey</surname>
                  </persName>
                  <idno type="halauthorid">1018062-0</idno>
                  <affiliation ref="#struct-205059"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Annette</forename>
                    <surname>von Scheven</surname>
                  </persName>
                  <idno type="halauthorid">2120887-0</idno>
                  <affiliation ref="#struct-329903"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laetitia</forename>
                    <surname>Sparsa</surname>
                  </persName>
                  <idno type="halauthorid">2120888-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Valérie</forename>
                    <surname>Devauchelle-Pensec</surname>
                  </persName>
                  <idno type="halauthorid">658544-0</idno>
                  <affiliation ref="#struct-486351"/>
                  <affiliation ref="#struct-454221"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sandrine</forename>
                    <surname>Jousse-Joulin</surname>
                  </persName>
                  <idno type="halauthorid">658509-0</idno>
                  <affiliation ref="#struct-486351"/>
                  <affiliation ref="#struct-412239"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11454</idno>
                <idno type="issn">1462-0324</idno>
                <idno type="eissn">1462-0332</idno>
                <title level="j">Rheumatology</title>
                <imprint>
                  <publisher>Oxford University Press (OUP)</publisher>
                  <biblScope unit="volume">60</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">3579-3587</biblScope>
                  <date type="datePub">2021-08-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/rheumatology/keaa804</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">juvenile idiopathic arthritis, reliability, scoring system, synovitis, ultrasonography</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.mhep.rsoa">Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system</classCode>
              <classCode scheme="halDomain" n="sdv.ib.ima">Life Sciences [q-bio]/Bioengineering/Imaging</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Abstract Objectives To evaluate the reliability of the OMERACT paediatric ultrasound (US) synovitis definitions and scoring system in JIA. Methods Thirteen sonographers analysed 75 images for the presence/absence of elementary lesions (binary scoring) and for grading synovitis, synovial hypertrophy, effusion and Doppler signals. Static US images of the second metacarpophalangeal joint (MCP-II), wrist, elbow, knee and ankle in JIA patients at different ages and different disease stages were collected with standardized scanning by two experienced sonographers. Intra- and inter-reader reliability were analysed with kappa coefficients. Results Intra-reader reliability was good for binary scoring (Cohen’s kappa 0.62, range 0.47–0.75), synovitis and synovial hypertrophy; excellent for Doppler signals (quadratic weighted kappa 0.77, 0.66–0.86; 0.76, 0.61–0.84; and 0.87, 0.77–0.94, respectively); and moderate for effusion (0.55, 0.24–0.76). Inter-reader reliability was good for synovitis and synovial hypertrophy (Light’s kappa 0.68, 95% CI: 0.61, 0.75 and 0.63, 0.54–0.71, respectively), excellent for Doppler signals (0.85, 95% CI: 0.77, 0.90), and moderate for binary scoring and effusion (0.48, 95% CI: 0.36, 0.64 and 0.49, 0.40–0.60, respectively). We obtained the best scores for the knee (0.71, 0.54–0.85) except for Doppler signals, with reliability higher for MCP-II. We found a trend toward better results in older children. Conclusions This is the first study establishing the reliability of the OMERACT paediatric US synovitis definitions and scoring system in the five most commonly affected joints in JIA. The reliability was good among a large group of sonographers. These results support the applicability of these definitions and scoring system in clinical practice and multicentre studies.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regrouplaboratory" xml:id="struct-1003702" status="INCOMING">
          <orgName>Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [Le Kremlin-Bicêtre]</orgName>
          <orgName type="acronym">CeRéMAIA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-312432" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-414766" status="VALID">
          <orgName>Hôpital Necker - Enfants Malades [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>149 Rue de Sèvres 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hopital-necker.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300210" status="VALID">
          <idno type="IdRef">030351189</idno>
          <idno type="ROR">https://ror.org/03n6vs369</idno>
          <orgName>Hôpital Avicenne [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chu93.aphp.fr/hopital-avicenne-bobigny/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1001049" status="VALID">
          <orgName>Physiopathologie, cibles et thérapies de la polyarthrite rhumatoïde</orgName>
          <orgName type="acronym">Li2P</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>UFR de Santé, Médecine et Biologie Humaine, Université Paris 13, 74 rue Marcel Cachin, 93017 Bobigny cedex.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris13.fr/li2p/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303171" type="direct"/>
            <relation active="#struct-303552" type="direct"/>
            <relation name="U1125" active="#struct-303623" type="direct"/>
            <relation active="#struct-581146" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300153" status="VALID">
          <idno type="ROR">https://ror.org/05n7yzd13</idno>
          <orgName>Hôpital Paul Brousse</orgName>
          <desc>
            <address>
              <addrLine>12 Avenue Paul Vaillant Couturier, 94800 Villejuif</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1066727" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-475859" status="VALID">
          <orgName>Hôpital Nord Franche-Comté [Hôpital de Trévenans]</orgName>
          <orgName type="acronym">HNFC</orgName>
          <desc>
            <address>
              <addrLine>90 Trévenans</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.hnfc.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-494389" status="VALID">
          <orgName>Third Department of Pediatric [Athens, Greece]</orgName>
          <desc>
            <address>
              <addrLine>1 Rimini Str, 12464 – Haidari Athens.</addrLine>
              <country key="GR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-307791" type="direct"/>
            <relation active="#struct-327339" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-211628" status="VALID">
          <idno type="IdRef">030378842</idno>
          <idno type="ROR">https://ror.org/04bckew43</idno>
          <orgName>Hôpitaux Universitaires de Strasbourg</orgName>
          <orgName type="acronym">HUS</orgName>
          <desc>
            <address>
              <addrLine>1 place de l'hôpital BP 426 67091 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300449" status="VALID">
          <idno type="ISNI">0000 0004 0387 6489</idno>
          <idno type="ROR">https://ror.org/03hf69k85</idno>
          <idno type="Wikidata">Q2904021</idno>
          <orgName>BIOMERIEUX [Lyon, France]</orgName>
          <desc>
            <address>
              <addrLine>376, chemin de l'Orme. 69280 Marcy l'Etoile.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.biomerieux.com/en/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-542281" status="VALID">
          <orgName>Département de Pédiatrie [Rennes] = Paediatrics [Rennes]</orgName>
          <desc>
            <address>
              <addrLine>CHU Rennes</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-301327" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-angers.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-204321" status="VALID">
          <orgName>Unité de rééducation neurologique pédiatrique [Bicêtre]</orgName>
          <desc>
            <address>
              <addrLine>Département de Pédiatrie - 78 rue du Gal Leclerc, 94275 Le Kremlin Bicêtre</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-312432" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-14059" status="VALID">
          <idno type="ROR">https://ror.org/03xzagw65</idno>
          <orgName>Hôpital Lapeyronie [CHU Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>371, avenue du Doyen Gaston Giraud - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/a-propos-du-chu/decouvrir/etablissements/lapeyronie</ref>
          </desc>
          <listRelation>
            <relation active="#struct-258773" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1062542" status="OLD">
          <idno type="RNSR">202123741U</idno>
          <orgName>Institut Desbrest d'Epidémiologie et de Santé Publique</orgName>
          <orgName type="acronym">IDESP</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Institut Universitaire de Recherche Clinique641 Avenue du Doyen Gaston Giraud34093 Montpellier</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UA 11" active="#struct-303623" type="direct"/>
            <relation active="#struct-410122" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-535102" status="INCOMING">
          <orgName>Clinique Universitaire de Pédiatrie [CHU Grenoble Alpes]</orgName>
          <desc>
            <address>
              <addrLine>Grenoble</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-484459" type="direct"/>
            <relation active="#struct-529864" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-442527" status="INCOMING">
          <orgName>Centre hospitalier de Chartres (Chartres)</orgName>
          <desc>
            <address>
              <addrLine>34 Rue du Dr Maunoury 28000 Chartres</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-205059" status="VALID">
          <idno type="ROR">https://ror.org/006yspz11</idno>
          <orgName>Hôpital Femme Mère Enfant [CHU - HCL]</orgName>
          <orgName type="acronym">HFME</orgName>
          <desc>
            <address>
              <addrLine>59 boulevard Pinel 69677 Bron</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hopital-femme-mere-enfant</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-329903" status="VALID">
          <idno type="IdRef">066756820</idno>
          <idno type="ROR">https://ror.org/05a353079</idno>
          <orgName>Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]</orgName>
          <orgName type="acronym">CHUV</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>Rue du Bugnon 21CH-1011 Lausanne, Vaud</addrLine>
              <country key="CH"/>
            </address>
            <ref type="url">https://www.chuv.ch/fr/chuv-home</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-486351" status="VALID">
          <idno type="RNSR">201722606C</idno>
          <orgName>Lymphocytes B, Autoimmunité et Immunothérapies</orgName>
          <orgName type="acronym">LBAI</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>5 Foch - CHU Morvan - BP 824 - 29609 Brest - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://nouveau.univ-brest.fr/lbai/fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300314" type="direct"/>
            <relation name="U1227" active="#struct-303623" type="direct"/>
            <relation active="#struct-303644" type="direct"/>
            <relation active="#struct-1083366" type="indirect"/>
            <relation active="#struct-519898" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-454221" status="VALID">
          <idno type="ROR">https://ror.org/03evbwn87</idno>
          <orgName>Hôpital Morvan - CHRU de Brest</orgName>
          <orgName type="acronym">CHU - BREST</orgName>
          <desc>
            <address>
              <addrLine>2 Avenue Maréchal Foch, 29200 Brest</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-412239" status="VALID">
          <orgName>CHRU Brest - Service de Rhumatologie</orgName>
          <orgName type="acronym">CHU - BREST - Rhumato</orgName>
          <desc>
            <address>
              <addrLine>Hôpital de la Cavale Blanche, Boulevard Tanguy Prigent, 29200 Brest</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-356603" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-312432" status="VALID">
          <orgName>Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]</orgName>
          <desc>
            <address>
              <addrLine>78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hopital-bicetre.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-303171" status="VALID">
          <idno type="IdRef">19077990X</idno>
          <idno type="ROR">https://ror.org/001z21q04</idno>
          <orgName>Université Sorbonne Paris Cité</orgName>
          <orgName type="acronym">USPC</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303552" status="VALID">
          <orgName>UFR Santé, Médecine et Biologie Humaine</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-581146" status="VALID">
          <idno type="IdRef">02640463X</idno>
          <idno type="ISNI">0000000121496883</idno>
          <idno type="ROR">https://ror.org/0199hds37</idno>
          <orgName>Université Sorbonne Paris Nord</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>99, avenue Jean-Baptiste Clément, 93430 Villetaneuse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-paris13.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1066727" status="VALID">
          <orgName>AP-HP. Université Paris Saclay</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.aphp.fr/groupes-hospitaliers-de-lap-hp</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-307791" status="VALID">
          <orgName>University of Athens Medical School [Athens]</orgName>
          <desc>
            <address>
              <addrLine>Athens 115 27</addrLine>
              <country key="GR"/>
            </address>
            <ref type="url">http://school.med.uoa.gr/en/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-327339" status="VALID">
          <orgName>“Attikon” University Hospital</orgName>
          <desc>
            <address>
              <addrLine>Rimini 1, P.O. 124 62, Haidari, Athens</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://attikonhospital.gov.gr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-258773" status="VALID">
          <idno type="ISNI">000000009961060X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
          <orgName type="acronym">CHRU Montpellier</orgName>
          <desc>
            <address>
              <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-484459" status="INCOMING">
          <orgName>Hôpital Sud, CHU de Grenoble</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-529864" status="INCOMING">
          <orgName>Hôpital Couple Enfant de Grenoble</orgName>
          <desc>
            <address>
              <addrLine>BP 217 - 38043  Grenoble Cedex 09</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300314" status="VALID">
          <idno type="IdRef">291809022</idno>
          <idno type="ISNI">0000000121880893</idno>
          <idno type="ROR">https://ror.org/0372th171</idno>
          <orgName>Université de Brest</orgName>
          <orgName type="acronym">UBO EPE</orgName>
          <desc>
            <address>
              <addrLine>Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-brest.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-303644" status="VALID">
          <orgName>LabEX IGO Immunothérapie Grand Ouest</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1083366" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1083366" status="VALID">
          <idno type="IdRef">258086599</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Nantes Université</orgName>
          <orgName type="acronym">Nantes Univ</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-519898" status="VALID">
          <idno type="RNSR">201722456P</idno>
          <orgName>Institut Brestois Santé Agro Matière</orgName>
          <orgName type="acronym">IBSAM</orgName>
          <date type="start">2017-10-12</date>
          <desc>
            <address>
              <addrLine>Université de Brest- UBO29238 Brest</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-brest.fr/menu/recherche-innovation/Laboratoires/Axe+Sant%C3%A9-+Agro-+Mati%C3%A8re/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300314" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-356603" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Brest</orgName>
          <orgName type="acronym">CHRU Brest</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>