Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea–An Analysis From the SERVE-HF Major Substudy - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Cardiovascular Medicine Année : 2022

Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea–An Analysis From the SERVE-HF Major Substudy

Christoph Fisser
  • Fonction : Auteur
Lara Gall
  • Fonction : Auteur
Jannis Bureck
  • Fonction : Auteur
Victoria Vaas
  • Fonction : Auteur
Jörg Priefert
  • Fonction : Auteur
Sabine Fredersdorf
  • Fonction : Auteur
Florian Zeman
  • Fonction : Auteur
Dominik Linz
  • Fonction : Auteur
Holger Woehrle
  • Fonction : Auteur
Helmut Teschler
  • Fonction : Auteur
Martin R Cowie
  • Fonction : Auteur
Michael Arzt
  • Fonction : Auteur
  • PersonId : 1143832

Résumé

Background: The SERVE-HF trial investigated the effect of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with heart failure with reduced ejection fraction (HFrEF). Objective: The aim of the present ancillary analysis of the SERVE-HF major substudy (NCT01164592) was to assess the effects of ASV on the burden of nocturnal ventricular arrhythmias as one possible mechanism for sudden cardiac death in ASV-treated patients with HFrEF and CSA. Methods: Three hundred twelve patients were randomized in the SERVE-HF major substudy [no treatment of CSA (control) vs. ASV]. Polysomnography including nocturnal ECG fulfilling technical requirements was performed at baseline, and at 3 and 12 months. Premature ventricular complexes (events/h of total recording time) and non-sustained ventricular tachycardia were assessed. Linear mixed models and generalized linear mixed models were used to analyse differences between the control and ASV groups, and changes over time. Results: From baseline to 3-and 12-month follow-up, respectively, the number of premature ventricular complexes (control: median 19.7, 19.0 and 19.0; ASV: 29.1, 29.0 Fisser et al. Effects of ASV on Arrhythmias and 26.0 events/h; p = 0.800) and the occurrence of ≥1 non-sustained ventricular tachycardia/night (control: 18, 25, and 18% of patients; ASV: 24, 16, and 24% of patients; p = 0.095) were similar in the control and ASV groups. Conclusion: Addition of ASV to guideline-based medical management had no significant effect on nocturnal ventricular ectopy or tachyarrhythmia over a period of 12 months in alive patients with HFrEF and CSA. Findings do not further support the hypothesis that ASV may lead to sudden cardiac death by triggering ventricular tachyarrhythmia.
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hal-03700368 , version 1 (21-06-2022)

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Christoph Fisser, Lara Gall, Jannis Bureck, Victoria Vaas, Jörg Priefert, et al.. Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea–An Analysis From the SERVE-HF Major Substudy. Frontiers in Cardiovascular Medicine, 2022, 9, ⟨10.3389/fcvm.2022.896917⟩. ⟨hal-03700368⟩

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