Therapeutic prevention of COVID-19 in elderly: a case-control study. - Archive ouverte HAL
Article Dans Une Revue AGE Année : 2021

Therapeutic prevention of COVID-19 in elderly: a case-control study.

Thomas Vogel
  • Fonction : Auteur
  • PersonId : 1049630
Benoit Schorr
  • Fonction : Auteur
  • PersonId : 1124876
Elise Schmitt
  • Fonction : Auteur
  • PersonId : 1136390
Patrick Karcher
  • Fonction : Auteur
  • PersonId : 1083905

Résumé

COVID-19 is a particularly aggressive disease for the elderly as 86% of deaths related to COVID-19 occur in people over 65 years of age. Despite the urgent need for a preventive treatment, there are currently no serious leads, other than the vaccination. The aim of this retrospective case-control study is to find a pharmacological preventive treatment of COVID-19 in elderly patients. One-hundred-seventy-nine patients had been in contact with other COVID-19 patients at home or in hospital, of whom 89 had tested RT-PCR-positive (COVID-pos) for the virus and 90 had tested RT-PCR-negative (COVID-neg). Treatments within 15 days prior to RT-PCR (including antihypertensive drugs, antipsychotics, antibiotics, nonsteroidal anti-inflammatory drugs, proton pump inhibitors (PPIs), oral antidiabetics (OADs), corticosteroids, immunosuppressants), comorbidities, symptoms, laboratory values, and clinical outcome were all collected. COVID-pos patients more frequently had a history of diabetes (P = .016) and alcoholism (P = .023), a lower leukocyte count (P = .014) and a higher mortality rate — 29.2% versus 14.4% — (P = .014) when compared to COVID-neg patients. Patients on PPIs were 2.3 times less likely (odds ratio [OR] = 0.4381, 95% confidence interval [CI] [0.2331, 0.8175], P = .0053) to develop COVID-19 infection, compared to those not on PPIs. No other treatment decreased or increased this risk. COVID-pos patients on antipsychotics (P = .0013) and OADs (P = .0153), particularly metformin (P = .0237), were less likely to die. Thus, patients on treatment with PPI were less likely to develop COVID-19 infection, and those on antipsychotics or metformin had a lower risk of mortality. However, prospective studies, including clinical trials, are needed to confirm or not these findings.

Dates et versions

hal-03700146 , version 1 (20-06-2022)

Identifiants

Citer

Frédéric Blanc, Cédric Waechter, Thomas Vogel, Benoit Schorr, Catherine Demuynck, et al.. Therapeutic prevention of COVID-19 in elderly: a case-control study.. AGE, 2021, 43 (5), pp.2333-2343. ⟨10.1007/s11357-021-00397-z⟩. ⟨hal-03700146⟩
75 Consultations
0 Téléchargements

Altmetric

Partager

More