iBIS2Analyzer: a web server for a phylogeny-driven coevolution analysis of protein families - Archive ouverte HAL Access content directly
Journal Articles Nucleic Acids Research Year : 2022

iBIS2Analyzer: a web server for a phylogeny-driven coevolution analysis of protein families

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Abstract

Residue coevolution within and between proteins is used as a marker of physical interaction and/or residue functional cooperation. Pairs or groups of coevolving residues are extracted from multiple sequence alignments based on a variety of computational approaches. However, coevolution signals emerging in subsets of sequences might be lost if the full alignment is considered. iBIS2Analyzer is a web server dedicated to a phylogeny-driven coevolution analysis of protein families with different evolutionary pressure. It is based on the iterative version, iBIS2, of the coevolution analysis method BIS, Blocks in Sequences. iBIS2 is designed to iteratively select and analyse subtrees in phylogenetic trees, possibly large and comprising thousands of sequences. With iBIS2Analyzer, openly accessible at http://ibis2analyzer.lcqb.upmc.fr/, the user visualizes, compares and inspects clusters of coevolving residues by mapping them onto sequences, alignments or structures of choice, greatly simplifying downstream analysis steps. A rich and interactive graphic interface facilitates the biological interpretation of the results.

Dates and versions

hal-03700047 , version 1 (20-06-2022)

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Cite

Francesco Oteri, Edoardo Sarti, Francesca Nadalin, Alessandra Carbone. iBIS2Analyzer: a web server for a phylogeny-driven coevolution analysis of protein families. Nucleic Acids Research, 2022, 50 (W1), pp.W412-W419. ⟨10.1093/nar/gkac481⟩. ⟨hal-03700047⟩
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