The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA - Archive ouverte HAL Access content directly
Journal Articles Molecular Plant Year : 2022

The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA

(1) , (1) , (2) , (1) , (1) , (1) , (2) , (3) , (1) , (1)
1
2
3

Abstract

Clustered organization of biosynthetic non-homologous genes is emerging as a characteristic feature of plant genomes. The co-regulation of clustered genes seems to largely depend on epigenetic reprogramming and three-dimensional chromatin conformation. In this study, we identified the long non-coding RNA (lncRNA) MARneral Silencing (MARS), localized inside the Arabidopsis marneral cluster, which controls the local epigenetic activation of its surrounding region in response to abscisic acid (ABA). MARS modulates the POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) component LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binding throughout the cluster in a dose-dependent manner, determining H3K27me3 deposition and chromatin condensation. In response to ABA, MARS decoys LHP1 away from the cluster and promotes the formation of a chromatin loop bringing together the MARNERAL SYNTHASE 1 (MRN1) locus and a distal ABA-responsive enhancer. The enrichment of co-regulated lncRNAs in clustered metabolic genes in Arabidopsis suggests that the acquisition of novel non-coding transcriptional units may constitute an additional regulatory layer driving the evolution of biosynthetic pathways
Fichier principal
Vignette du fichier
author_file.pdf (1.36 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03698779 , version 1 (19-06-2022)

Identifiers

Cite

Thomas Roulé, Aurelie Christ, Nosheen Hussain, Ying Huang, Caroline Hartmann, et al.. The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA. Molecular Plant, 2022, 15 (5), pp.1-58. ⟨10.1016/j.molp.2022.02.007⟩. ⟨hal-03698779⟩
10 View
73 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More