Molecular imaging of endocrine neoplasms with emphasis on 18F-DOPA PET: a practical approach for well-tailored imaging protocols - Archive ouverte HAL
Article Dans Une Revue The Quarterly Journal of Nuclear Medicine and Molecular Imaging Année : 2022

Molecular imaging of endocrine neoplasms with emphasis on 18F-DOPA PET: a practical approach for well-tailored imaging protocols

Résumé

6-[18F]-L-fluoro-L-3, 4-dihydroxyphenylalanine (18F-DOPA) PET/CT can be a useful tool for the detection of different neuroendocrine tumors (NETs). The main determinants of 18F-DOPA uptake and retention by NETs are related to expression of LAT1/LAT2 transporters, expression and activity of AADC and biochemical phenotype, all being intimately inter-connected to their embryological origin. In order to improve sensitivity of 18F-DOPA PET, it is of main importance to perform indivisualized imaging protocols across primaries. This review provides a practical approach for performing well-tailored imaging protocols and describes the clinical value of the recommended radiopharmaceuticals.
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Dates et versions

hal-03697192 , version 1 (16-06-2022)

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Citer

Christelle Fargette, Alessio Imperiale, David Taïeb. Molecular imaging of endocrine neoplasms with emphasis on 18F-DOPA PET: a practical approach for well-tailored imaging protocols. The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2022, 66 (2), pp.141-147. ⟨10.23736/s1824-4785.22.03450-1⟩. ⟨hal-03697192⟩
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