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                <term xml:lang="en">μCT</term>
                <term xml:lang="en">B-mode</term>
                <term xml:lang="en">air pockets</term>
                <term xml:lang="en">scattering</term>
                <term xml:lang="en">tablet swelling</term>
                <term xml:lang="en">tablet disintegration</term>
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              <p>Controlled disintegration of pharmaceutical tabletshas been of interest for consistency checks and drug delivery. Under sonication, tablet disintegration is accelerated. This acceleration has been attributed to the existence of microscopic air pockets inside compacted tablets. In this study, we investigated the existence of such pockets by subjecting tablets to micro-computed tomography. In addition, we subjected tablets from  the  same  batch  to  sonography.  The  tablets  were  measured to have an ultrasonic swelling rate of 162±16 μm s$^{-1}$.The  micro-computed  tomography  images  showed  air  pockets  of  up  to  9 μm  in  diameter,  some  of  which  were  visibly connected to each other. The brightness-mode images showed scattering from inside the tablets, suggesting cavitation activity. We conclude that, inside the tablets investigated, microscopic air entrapments exist, whose pulsations are detectable with brightness-mode ultrasound</p>
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