Slowly‐adapting type II afferents contribute to conscious touch sensation in humans: Evidence from single unit intraneural microstimulation - Archive ouverte HAL Access content directly
Journal Articles The Journal of Physiology Year : 2022

Slowly‐adapting type II afferents contribute to conscious touch sensation in humans: Evidence from single unit intraneural microstimulation

Abstract

Slowly-adapting type II (SA-II, Ruffini) mechanoreceptive afferents respond well to pressure and stretch, and are regularly encountered in human microneurography studies. Despite an understanding of SA-II response properties, their role in touch perception remains unclear. Specific roles of different myelinated Aβ mechanoreceptive afferents in tactile perception have been revealed using single unit intraneural microstimulation (INMS), via microneurography, recording from and then electrically stimulating individual afferents. This method directly links single afferent artificial activation to perception, where INMS produces specific ‘quantal’ touch percepts associated with different mechanoreceptive afferent types. However, SA-II afferent stimulation has been ambiguous, producing inconsistent, vague sensations, or no clear percept. We physiologically characterized hundreds of individual Aβ mechanoreceptive afferents in the glabrous hand skin and examined the subsequent percepts evoked by trains of low amplitude INMS current pulses (<10 μA). We present 18 SA-II afferents where INMS resulted in a clear, electrically evoked sensation of large (∼36 mm2) diffuse pressure, which was projected precisely to their physiologically-defined receptive field in the skin. This sensation was felt as natural, distinctive from other afferents, and showed no indications of multi-afferent stimulation. Stimulus frequency modulated sensation intensity and even brief stimuli (4 pulses, 60 ms) were perceived. These results suggest that SA-II afferents contribute to perceived tactile sensations, can signal this rapidly and precisely, and are relevant and important for computational models of touch sensation and artificial prosthetic feedback.
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Dates and versions

hal-03695894 , version 1 (15-06-2022)

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Roger Holmes Watkins, Mario Durao de Carvalho Amante, Helena Backlund Wasling, Johan Wessberg, Rochelle Ackerley. Slowly‐adapting type II afferents contribute to conscious touch sensation in humans: Evidence from single unit intraneural microstimulation. The Journal of Physiology, 2022, 600 (12), pp.2939 - 2952. ⟨10.1113/jp282873⟩. ⟨hal-03695894⟩
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