Metal halide perovskites have recently emerged as one of the most promising classes of semiconductors for various applications, especially in the field of optoelectronics. Lead-based halide perovskite materials, virtually unexploited for decades, have become prominent candidates due to their unique and intrinsic physicochemical and optical properties. Current challenges faced by the scientific community to capitalize on the properties of Pb-based perovskites are mainly associated with environmental concerns due to the toxicity of Pb and their poor stability. Under this context, over recent years, a number of new Pb-free halide perovskite (and perovskite-like) semiconductor classes have been introduced. This Perspective reviews recent developments in Pb-free halide perovskites, which specifically target their application in solar cells, light-emitting devices, and photocatalysts. Each type of Pb-free material is paired with a specific optoelectronic application, and the latest record performances are reported. Although these materials do not yet exhibit as attractive intrinsic optoelectronic properties as the Pb-based halide perovskites, their potential as alternatives for well-suited applications is discussed.