atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
Résumé
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance. © 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.
Mots clés
bedaquiline
quinoline derivative
tuberculostatic agent
genetics
human
microbial sensitivity test
multidrug resistant tuberculosis
mutation
Mycobacterium tuberculosis
treatment failure
Antitubercular Agents
Diarylquinolines
Humans
Microbial Sensitivity Tests
Mutation
Treatment Failure
Tuberculosis
Multidrug-Resistant
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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