The eruptive chronology of arc volcanoes consists of construction stages usually punctuated by large collapse events affecting the edifice. In this paper, we reconstruct the eruptive chronology of Carihuairazo volcano, a Middle Pleistocene edifice from the Ecuadorian segment of the Andean Northern Volcanic Zone. This study is based on extensive fieldwork on both the proximal flanks of the volcano and the medial-to-distal deposits of the nearby Ambato basin, as well as a large dataset of geochronological (40K-40Ar, 14C) and geochemical (major and trace element) data. The Basal Carihuairazo edifice is mainly composed of an andesitic lava flow succession dated at 230-200 ka. The resulting edifice suffered a first sector collapse that was responsible for a relatively large (4 ± 1 km3) debris avalanche deposit (DAD-1) that covers the entire Ambato basin. This event occurred between 206 ± 4 and 216 ± 5 ka. Then, Carihuairazo started a succession of construction (Intermediate and Terminal lava flow successions) and destruction stages lasting about 50 ky (i.e., from 200 to 150 ka), which are composed by thick block-and-ash flow deposits (L- and U-BAFD) and debris avalanche deposits (DAD-2). This volcanic succession is recorded in the Ambato basin, interlayered with several tephra fallout deposits (TFD-1 to -4) whose source is the neighbouring Huisla-Mulmul volcanic complex. The current morphology of Carihuairazo results from two additional sector collapses (DAD-3 and -4) that occurred during the past 40-50 ka, i.e., following a long period (at least 100 ka) without volcanic activity. We stress these debris avalanches were not related with magmatic activity. Samples from the Carihuairazo volcano defines a medium-K magmatic trend composed of andesites and dacites with a mineral assemblage of plagioclase, amphibole, ortho- and clino-pyroxene, and Fe–Ti oxides. The evolution of the Carihuairazo edifice, recorded in the medial-distal deposits of the Ambato basin, represents a unique example in the Ecuadorian arc of an edifice that experienced successive destruction and construction stages during a major part of its volcanic history.